Phospholipases A and Lysophospholipases in protozoan parasites - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Microbial Cell Année : 2023

Phospholipases A and Lysophospholipases in protozoan parasites

Résumé

Phospholipases (PLs) and Lysophospholipases (LysoPLs) are a diverse group of esterases responsible for phospholipid or lysophospholipid hydrolysis. They are involved in several biological processes, including lipid catabolism, modulation of the immune response and membrane maintenance. PLs are classified depending on their site of hydrolysis as PLA1, PLA2, PLC and PLD. In many pathogenic microorganisms, from bacteria to fungi, PLAs and LysoPLs have been described as critical virulence and/or pathogenicity factors. In protozoan parasites, a group containing major human and animal pathogens, growing literature show that PLAs and LysoPLs are also involved in the host infection. Their ubiquitous presence and role in host-pathogen interactions make them particularly interesting to study. In this review, we summarize the literature on PLAs and LysoPLs in several protozoan parasites of medical relevance, and discuss the growing interest for them as potential drug and vaccine targets.
Fichier principal
Vignette du fichier
PLAs and LysoPLs of protozoan.pdf (484.12 Ko) Télécharger le fichier
Origine Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-04242336 , version 1 (14-10-2023)

Identifiants

Citer

Perrine Hervé, Sarah Monic, Frédéric Bringaud, Loïc Rivière. Phospholipases A and Lysophospholipases in protozoan parasites. Microbial Cell , 2023, 10 (10), pp.204-216. ⟨10.15698/mic2023.10.805⟩. ⟨hal-04242336⟩

Collections

ANR FRM
2 Consultations
17 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More