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Article Dans Une Revue (Article De Synthèse) Molecular and Cellular Endocrinology Année : 2016

Estrogen-Related Receptors and the control of bone cell fate

Résumé

Bone loss is naturally occurring in aging males and females and exacerbated in the latter after menopause, altogether leading to cumulative skeleton fragility and increased fracture risk. Two types of therapeutic strategies can be envisioned to counteract age- or menopause-associated bone loss, aiming at either reducing bone resorption exerted by osteoclasts or, alternatively, promoting bone formation by osteoblasts. We here summarize data suggesting that inhibition of the Estrogen-Related Receptors α and/or γ could promote bone formation and compensate for bone loss induced by ageing or estrogen-deficiency.
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Dates et versions

hal-04242188 , version 1 (18-10-2023)

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Julie Carnesecchi, Jean-Marc Vanacker. Estrogen-Related Receptors and the control of bone cell fate. Molecular and Cellular Endocrinology, 2016, 432 (15), pp.37-43. ⟨10.1016/j.mce.2015.07.019⟩. ⟨hal-04242188⟩
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