Dietary restriction induces a sexually dimorphic type I interferon response in mice with gene-environment interactions - Archive ouverte HAL
Article Dans Une Revue Cell Reports Année : 2023

Dietary restriction induces a sexually dimorphic type I interferon response in mice with gene-environment interactions

Résumé

Intermittent fasting (IF) is an established intervention to treat the growing obesity epidemic. However, the interaction between dietary interventions and sex remains a significant knowledge gap. In this study, we use unbiased proteome analysis to identify diet-sex interactions. We report sexual dimorphism in response to intermittent fasting within lipid and cholesterol metabolism and, unexpectedly, in type I interferon signaling, which was strongly induced in females. We verify that secretion of type I interferon is required for the IF response in females. Gonadectomy differentially alters the every-other-day fasting (EODF) response and demonstrates that sex hormone signaling can either suppress or enhance the interferon response to IF. IF fails to potentiate a stronger innate immune response when IF-treated animals were challenged with a viral mimetic. Lastly, the IF response changes with genotype and environment. These data reveal an interesting interaction between diet, sex, and the innate immune system
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Dates et versions

hal-04241406 , version 1 (13-10-2023)

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Dylan J Harney, Michelle Cielesh, Georgia E Roberts, Isabelle K Vila, Barney Viengkhou, et al.. Dietary restriction induces a sexually dimorphic type I interferon response in mice with gene-environment interactions. Cell Reports, 2023, 42 (6), pp.112559. ⟨10.1016/j.celrep.2023.112559⟩. ⟨hal-04241406⟩
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