Organocuprate‐Initiated Domino Michael–Intramolecular Aldol Reaction – Application to the Formation of Ring B of the Aglycon of Landomycins - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue European Journal of Organic Chemistry Année : 2012

Organocuprate‐Initiated Domino Michael–Intramolecular Aldol Reaction – Application to the Formation of Ring B of the Aglycon of Landomycins

Xavier Bugaut

Résumé

Abstract An innovative access to a β,β‐disubstituted Morita–Baylis–Hillman motif, which is a potential intermediate en route to the synthesis of the aglycon of landomycins, is presented. It consists of a finely optimized organocuprate‐initiated domino Michael–intramolecular aldol reaction. The use of TMSCl and DMAP as additives proved essential to ensure the success of this reaction sequence.

Domaines

Chimie

Dates et versions

hal-04236811 , version 1 (11-10-2023)

Identifiants

Citer

Xavier Bugaut, Emmanuel Roulland. Organocuprate‐Initiated Domino Michael–Intramolecular Aldol Reaction – Application to the Formation of Ring B of the Aglycon of Landomycins. European Journal of Organic Chemistry, 2012, 2012 (5), pp.908-912. ⟨10.1002/ejoc.201101766⟩. ⟨hal-04236811⟩
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