Organocuprate‐Initiated Domino Michael–Intramolecular Aldol Reaction – Application to the Formation of Ring B of the Aglycon of Landomycins
Résumé
Abstract An innovative access to a β,β‐disubstituted Morita–Baylis–Hillman motif, which is a potential intermediate en route to the synthesis of the aglycon of landomycins, is presented. It consists of a finely optimized organocuprate‐initiated domino Michael–intramolecular aldol reaction. The use of TMSCl and DMAP as additives proved essential to ensure the success of this reaction sequence.