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Article Dans Une Revue Cell Metabolism Année : 2022

Glycolysis-derived L-serine levels versus PHGDH expression in Alzheimer’s disease

Résumé

Recent work from Bonvento and colleagues indicated that synaptic and memory deficits in early Alzheimer's disease (AD) are related to a shortage in L-serine production in astrocytes. Here, the authors, responding to correspondence from Chen and colleagues, discuss how this deficiency does not necessarily require a decrease in PHGDH expression and conclude that the primary event leading to lower serine production is more likely related to altered glycolytic flux in early AD than to PHGDH expression.

Dates et versions

hal-04236525 , version 1 (11-10-2023)

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Citer

Gilles Bonvento, Stéphane H.R. Oliet, Aude Panatier. Glycolysis-derived L-serine levels versus PHGDH expression in Alzheimer’s disease. Cell Metabolism, 2022, 34 (5), pp.654-655. ⟨10.1016/j.cmet.2022.04.002⟩. ⟨hal-04236525⟩
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