Use of Conglomerates Mixed Crystals to Deracemize a Stable Racemic‐Compound‐Forming System
Résumé
Deracemization extended to racemic-compound-forming systems is demonstrated. We present here the first results of an alternative for the resolution of systems that exhibit a stable racemic compound but also a closely related conglomerate-forming system. If the couples of enantiomers forming the racemic compound and the enantiomers of the stable conglomerate can syncrystallize in mirror related partial solid solutions, it is possible to deracemize the racemic mixture of mixed crystals to access to a single handedness. The evidence of that possibility is given on three examples by using Temperature Cycling Induced Deracemization.
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