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Article Dans Une Revue Emerging Infectious Diseases Année : 2023

Case Studies and Literature Review of Francisella tularensis –Related Prosthetic Joint Infection

Résumé

Tularemia is a zoonotic infection caused by Francisella tularensis. Its most typical manifestations in humans are ulceroglandular and glandular; infections in prosthetic joints are rare. We report 3 cases of F. tularensis subspecies holarctica-related prosthetic joint infection that occurred in France during 2016-2019. We also reviewed relevant literature and found only 5 other cases of Francisella-related prosthetic joint infections worldwide, which we summarized. Among those 8 patients, clinical symptoms appeared 7 days to 19 years after the joint placement and were nonspecific to tularemia. Although positive cultures are typically obtained in only 10% of tularemia cases, strains grew in all 8 of the patients. F. tularensis was initially identified in 2 patients by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry; molecular methods were used for 6 patients. Surgical treatment in conjunction with long-term antimicrobial treatment resulted in favorable outcomes; no relapses were seen after 6 months of follow-up.

Dates et versions

hal-04235894 , version 1 (10-10-2023)

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Léa Ponderand, Thomas Guimard, Estibaliz Lazaro, Henry Dupuy, Olivia Peuchant, et al.. Case Studies and Literature Review of Francisella tularensis –Related Prosthetic Joint Infection. Emerging Infectious Diseases, 2023, 29 (6), pp.1118-1126. ⟨10.3201/eid2906.221395⟩. ⟨hal-04235894⟩
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