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Pré-Publication, Document De Travail Année : 2023

Cue-Induced Drug Seeking and Its Association with Craving and Dependence in Cigarette Smokers

Résumé

Abstract Increased salience of drug-related cues over non-drug reinforcers can drive drug use behaviors and contribute to tobacco use disorder (TUD). An important scientific and clinical goal is to effectively measure this elevated drug-seeking behavior in TUD. However, most TUD assessments rely on self-reported cravings and cigarette consumption, not providing an objective measure of cue-induced drug seeking. The probabilistic image choice (PIC) task, initially developed and validated for cocaine use disorder (and since validated in users of methamphetamine and opioids), investigates the choice of viewing drug-related pictures as compared to other salient pictures (e.g., pleasant and unpleasant cues). This study aimed to develop and validate the PIC task for TUD and evaluate the associations between behavioral choice and tobacco craving, daily cigarette consumption, and nicotine dependence (the Fagerström score). We recruited 468 smokers and 121 nonsmokers using the Prolific online platform. Participants performed the PIC task twice (at a one-month interval) and completed other measures relevant to TUD. As expected, compared to nonsmokers, tobacco smokers selected to view significantly more tobacco images and less pleasant (non-drug reinforcer) images, a profile that remained stable at retest. Drug seeking on the PIC task was associated with craving but not with the other tobacco dependence measures, suggesting that the task is better at modeling current drug “wanting” rather than cumulative nicotine exposure or physical dependence. In conclusion, these results suggest that the PIC task can be a valuable tool for objectively assessing craving-associated tobacco seeking in TUD. Implications Current measures of tobacco use disorder (TUD) rely on self-reports of consumption, dependence and craving and do not take into consideration the role of drug-related cues in driving tobacco seeking. This study shows that the probabilistic image choice (PIC) task provides an objective, reliable proxy measure of drug-seeking behavior in cigarette smokers that is linked to craving and desire for smoking but not to other measures of TUD. Therefore, the PIC task may be a useful complementary tool for the classification, diagnosis, and prognosis of TUD.

Dates et versions

hal-04235601 , version 1 (10-10-2023)

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Marcello Solinas, Chauvet Claudia, Claire Lafay-Chebassier, Paul Vanderkam, Barillot Lila, et al.. Cue-Induced Drug Seeking and Its Association with Craving and Dependence in Cigarette Smokers. 2023. ⟨hal-04235601⟩
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