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Article Dans Une Revue (Article De Synthèse) Biomolecules Année : 2023

The Essentials on microRNA-Encoded Peptides From Plants to Animals

L'essentiel sur les peptides codés par des microANRs des plantes aux animaux

Résumé

Primary transcripts of microRNAs (pri-miRNAs) were initially defined as long non-coding RNAs that host miRNAs further processed by the microRNA processor complex. A few years ago, however, it was discovered in plants that pri-miRNAs actually contain functional open reading frames (sORFs) that translate into small peptides called miPEPs, for mi-croRNA-encoded peptides. Initially detected in Arabidopsis thaliana and Medicago truncatula, recent studies have revealed the presence of miPEPs in other pri-miRNAs as well as in other species ranging from various plant species to animals. This suggests that miPEP numbers remain largely underestimated and that they could be a common signature of pri-miRNAs. Here we present the most recent advances in miPEPs research and discuss how their discovery has broadened our vision of the regulation of gene expression by miRNAs, and how miPEPs could be interesting tools in sustainable agriculture or the treatment of certain human diseases.
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Dates et versions

hal-04234851 , version 1 (10-10-2023)

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Citer

Mélanie Ormancey, Patrice Thuleau, Jean-Philippe Combier, Serge Plaza. The Essentials on microRNA-Encoded Peptides From Plants to Animals. Biomolecules, 2023, 13 (2), pp.206. ⟨10.3390/biom13020206⟩. ⟨hal-04234851⟩
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