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Article Dans Une Revue Science Année : 2021

Environmental robustness of the global yeast genetic interaction network

Michael Costanzo
Jing Hou
Vincent Messier
Justin Nelson
Mahfuzur Rahman
Wen Wang
Matej Ušaj
Chad Myers
Charles Boone
Brenda Andrews

Résumé

Environmental impacts on gene networks A phenotype can be affected by genes interacting with other genes, the environment, or both other genes and the environment (a differential interaction). To better understand how these interactions function in yeast, Costanzo et al. mapped gene-gene interactions using single- and double-mutant deletions and temperature-sensitive alleles under 14 environmental conditions. Many deleted or temperature-sensitive nonessential genes affected yeast fitness both positively and negatively under at least one of the environmental conditions tested. In these cases, up to 24% of yeast genes were affected. A minority of these differential interactions point to previously unknown genetic connections across functional networks, informing on how genetic architecture responds to environmental variation. Science , this issue p. eabf8424

Dates et versions

hal-04234533 , version 1 (10-10-2023)

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Citer

Michael Costanzo, Jing Hou, Vincent Messier, Justin Nelson, Mahfuzur Rahman, et al.. Environmental robustness of the global yeast genetic interaction network. Science, 2021, 372 (6542), ⟨10.1126/science.abf8424⟩. ⟨hal-04234533⟩
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