Cutaneous vasculitis occurring in the setting of systemic lupus erythematosus: a multicentre cohort study - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Rheumatology Année : 2023

Cutaneous vasculitis occurring in the setting of systemic lupus erythematosus: a multicentre cohort study

Paul Breillat
Marie Jachiet
  • Fonction : Auteur
Yoan Ditchi
  • Fonction : Auteur
Cédric Lenormand
  • Fonction : Auteur
Nathalie Costedoat-Chalumeau
  • Fonction : Auteur
Alexis Mathian
Philippe Moguelet
  • Fonction : Auteur
Paul Duriez
  • Fonction : Auteur
Marten Trendelenburg
  • Fonction : Auteur
Uyen Huynh-Do
  • Fonction : Auteur
Carlo Chizzolini
  • Fonction : Auteur
Clément Beuvon
Frederique Roy-Peaud
  • Fonction : Auteur
Jean-David Bouaziz
  • Fonction : Auteur
Annick Barbaud
Camille Francès
  • Fonction : Auteur
Arsène Mékinian
Olivier Fain
Zahir Amoura
  • Fonction : Auteur
François Chasset
  • Fonction : Auteur
Nadège Cordel
Dan Lipsker
  • Fonction : Auteur
Charles Cassius
  • Fonction : Auteur
Camillo Ribi
  • Fonction : Auteur

Résumé

Abstract Objectives To describe the clinical and pathological features of biopsy-proven cutaneous vasculitis (CV) associated with SLE, focusing on diagnosis classification and impact on overall SLE activity. Methods Retrospective multicentric cohort study including SLE patients with biopsy-proven CV identified by (i) data from pathology departments of three university hospitals and (ii) a national call for cases. SLE was defined according to 1997 revised ACR and/or 2019 ACR/EULAR criteria. CV diagnosis was confirmed histologically and classified by using the dermatological addendum of the Chapel Hill classification. SLE activity and flare severity at the time of CV diagnosis were assessed independently of vasculitis items with the SELENA-SLEDAI and SELENA-SLEDAI Flare Index. Results Overall, 39 patients were included; 35 (90%) were female. Cutaneous manifestations included mostly palpable purpura (n = 21; 54%) and urticarial lesions (n = 18; 46%); lower limbs were the most common location (n = 33; 85%). Eleven (28%) patients exhibited extracutaneous vasculitis. A higher prevalence of Sjögren’s syndrome (51%) was found compared with SLE patients without CV from the French referral centre group (12%, P < 0.0001) and the Swiss SLE Cohort (11%, P < 0.0001). CV was mostly classified as urticarial vasculitis (n = 14, 36%) and cryoglobulinaemia (n = 13, 33%). Only 2 (5%) patients had no other cause than SLE to explain the CV. Sixty-one percent of patients had inactive SLE. Conclusion SLE-related vasculitis seems very rare and other causes of vasculitis should be ruled out before considering this diagnosis. Moreover, in more than half of patients, CV was not associated with another sign of active SLE.
Fichier non déposé

Dates et versions

hal-04233679 , version 1 (09-10-2023)

Identifiants

Citer

Paul Breillat, Marie Jachiet, Yoan Ditchi, Cédric Lenormand, Nathalie Costedoat-Chalumeau, et al.. Cutaneous vasculitis occurring in the setting of systemic lupus erythematosus: a multicentre cohort study. Rheumatology, 2023, 62 (6), pp.2189-2196. ⟨10.1093/rheumatology/keac566⟩. ⟨hal-04233679⟩
2 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More