Obesity, Overweight, and Pituitary Stalk Interruption Syndrome in Children and Young Adults - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Clinical Endocrinology and Metabolism Année : 2023

Obesity, Overweight, and Pituitary Stalk Interruption Syndrome in Children and Young Adults

Résumé

Context : Pituitary stalk interruption syndrome (PSIS) is rare in the pediatric population. It combines ectopic posterior pituitary stalk interruption and anterior pituitary hypoplasia with hormonal deficiencies. The phenotype is highly heterogeneous and obesity/overweight seems to be underreported in the literature. Objective : To identify patients with PSIS and obesity or overweight, describe their phenotype, and compare them with patients with PSIS without overweight/obesity. Methods : Sixty-nine children and young adults with PSIS in a Toulouse cohort from 1984 to 2019 were studied. We identified 25 obese or overweight patients (OB-OW group), and 44 were nonobese/overweight (NO group). Then the groups were compared. Results : All cases were sporadic. The sex ratio was 1.6. The main reason for consultation in both groups was growth retardation (61% in OB-OW group, 77% in NO group). History of neonatal hypoglycemia was more common in the OB-OW than in the NO group (57% vs 14%, P = .0008), along with extrapituitary malformations (64% vs 20%, P < 0001). The incidence of caesarean section was higher in the OB-OW group (52%) than in the NO group (23%), although not significant (P = .07). Conclusion Patients with PSIS who are obese/overweight display interesting phenotypic differences that suggest hypothalamic defects. Studies are needed that include additional information on hormonal levels, particularly regarding oxytocin and ghrelin.

Dates et versions

hal-04233001 , version 1 (09-10-2023)

Identifiants

Citer

Gaëlle Nannette, Céline Bar, Gwenaëlle Diene, Catherine Pienkowski, Isabelle Oliver-Petit, et al.. Obesity, Overweight, and Pituitary Stalk Interruption Syndrome in Children and Young Adults. Journal of Clinical Endocrinology and Metabolism, 2023, 108 (2), pp.323-330. ⟨10.1210/clinem/dgac583⟩. ⟨hal-04233001⟩
39 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More