Pregnancy and post-partum in patients with myelin-oligodendrocyte glycoprotein antibody-associated disease - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Multiple Sclerosis Journal Année : 2023

Pregnancy and post-partum in patients with myelin-oligodendrocyte glycoprotein antibody-associated disease

Aurélie Ruet
Elisabeth Maillart

Résumé

Background and objective: Myelin-oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) frequently initiates during childbearing years. This study investigated the impact of pregnancy and post-partum on MOGAD activity. Methods: Retrospective analysis of clinical and demographic data from a multicenter French cohort of adult patients with MOGAD. All adult female patients who had a pregnancy after disease onset or in the year before disease onset were included. The annualized relapse rate was evaluated in patients who had a pregnancy after disease onset, to evaluate the impact of pregnancy and post-partum on MOGAD course. Results: Twenty-five informative pregnancies after disease onset were identified. No relapse was recorded during these pregnancies and only three relapses occurred during the first 3 months post-partum. The annualized relapse rate decreased from 0.67 (95% confidence interval: 0.40–1.10) during the pre-pregnancy period to 0 (95% confidence interval: 0–0.21) during pregnancy and to 0.22 (95% confidence interval: 0.09–0.53) during the first year post-partum. Among 144 female patients in their childbearing age recorded in the database, 18 (12.5%) reported their first symptoms during pregnancy or in the 12 months post-partum. Discussion: Our study suggests a marked reduction of MOGAD relapse rate during pregnancy and the post-partum period. Prospective studies on the role of pregnancy and delivery in MOGAD course are needed.

Domaines

Immunologie
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Dates et versions

hal-04229826 , version 1 (05-10-2023)

Identifiants

Citer

Clarisse Carra-Dallière, Fabien Rollot, Romain Deschamps, Jonathan Ciron, Sandra Vukusic, et al.. Pregnancy and post-partum in patients with myelin-oligodendrocyte glycoprotein antibody-associated disease. Multiple Sclerosis Journal, 2023, 29 (2), pp.270-276. ⟨10.1177/13524585221134214⟩. ⟨hal-04229826⟩
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