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Article Dans Une Revue Journal of Experimental Medicine Année : 2023

Autoantibodies neutralizing type I IFNs underlie West Nile virus encephalitis in ∼40% of patients

Adrian Gervais
Francesca Rovida
Maria Antonietta Avanzini
Stefania Croce
Astrid Marchal
Shih-Ching Lin
Alessandro Ferrari
Christian W Thorball
Orianne Constant
Tom Le Voyer
Quentin Philippot
Jérémie Rosain
Micol Angelini
Malena Pérez Lorenzo
Lucy Bizien
Cristian Achille
Francesca Trespidi
Elisa Burdino
Irene Cassaniti
Daniele Lilleri
Chiara Fornara
José Camilla Sammartino
Danilo Cereda
Chiara Marrocu
Antonio Piralla
Chiara Valsecchi
Stefano Ricagno
Paola Cogo
Olaf Neth
Inés Marín-Cruz
Monia Pacenti
Alessandro Sinigaglia
Marta Trevisan
Andrea Volpe
Antonio Marzollo
Francesca Conti
Tiziana Lazzarotto
Andrea Pession
  • Fonction : Auteur
Pierluigi Viale
Jacques Fellay
Stefano Ghirardello
Mélodie Aubart
Valeria Ghisetti
Alessandro Aiuti
Emmanuelle Jouanguy
Paul Bastard
Elena Percivalle
Fausto Baldanti
Anne Puel
Margaret R Macdonald
Charles M Rice
Giada Rossini
  • Fonction : Auteur
Kristy O Murray
Anna Nagy
  • Fonction : Auteur
Luisa Barzon
Laurent Abel
Michael S Diamond
Aurélie Cobat
Shen-Ying Zhang
Jean-Laurent Casanova
Alessandro Borghesi

Résumé

Mosquito-borne West Nile virus (WNV) infection is benign in most individuals but can cause encephalitis in <1% of infected individuals. We show that ∼35% of patients hospitalized for WNV disease (WNVD) in six independent cohorts from the EU and USA carry auto-Abs neutralizing IFN-α and/or-ω. The prevalence of these antibodies is highest in patients with encephalitis (∼40%), and that in individuals with silent WNV infection is as low as that in the general population. The odds ratios for WNVD in individuals with these auto-Abs relative to those without them in the general population range from 19.0 (95% CI 15.0-24.0, P value <10-15) for auto-Abs neutralizing only 100 pg/ml IFN-α and/or IFN-ω to 127.4 (CI 87.1-186.4, P value <10-15) for auto-Abs neutralizing both IFN-α and IFN-ω at a concentration of 10 ng/ml. These antibodies block the protective effect of IFN-α in Vero cells infected with WNV in vitro. Auto-Abs neutralizing IFN-α and/or IFN-ω underlie ∼40% of cases of WNV encephalitis. .
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Dates et versions

hal-04229658 , version 1 (05-10-2023)

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Adrian Gervais, Francesca Rovida, Maria Antonietta Avanzini, Stefania Croce, Astrid Marchal, et al.. Autoantibodies neutralizing type I IFNs underlie West Nile virus encephalitis in ∼40% of patients. Journal of Experimental Medicine, 2023, 220 (9), ⟨10.1084/jem.20230661⟩. ⟨hal-04229658⟩
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