Impact of long-term exposure to ambient ozone on lung function over a course of 20 years (The ECRHS study): a prospective cohort study in adults - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue The Lancet Regional Health - Europe Année : 2023

Impact of long-term exposure to ambient ozone on lung function over a course of 20 years (The ECRHS study): a prospective cohort study in adults

1 LMU - Ludwig Maximilian University [Munich] = Ludwig Maximilians Universität München
2 HMGU - Helmholtz Zentrum München = German Research Center for Environmental Health
3 University-Hospital Munich-Großhadern [München]
4 UJ - Uniwersytet Jagielloński w Krakowie = Jagiellonian University
5 Medical University of Plovdiv
6 Imperial College London
7 Swiss Tropical and Public Health Institute [Basel]
8 Unibas - Université de Bâle = University of Basel = Basel Universität
9 UNIVR - Università degli studi di Verona = University of Verona
10 IAB - Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble)
11 CHUGA - Centre Hospitalier Universitaire [CHU Grenoble]
12 UA - University of Antwerp
13 Umeå University, Sweden
14 ISGlobal - Instituto de Salud Global - Institute For Global Health [Barcelona]
15 UPF - Universitat Pompeu Fabra [Barcelona]
16 CIBERESP - Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública = Consortium for Biomedical Research of Epidemiology and Public Health
17 UNIPV - Università degli Studi di Pavia = University of Pavia
18 GU - Göteborgs Universitet = University of Gothenburg
19 Uppsala University
20 UiB - University of Bergen
21 German Center for Lung Research
22 CESP - Centre de recherche en épidémiologie et santé des populations
23 Hospital Universitario Juan Ramón Jiménez [Huelva]
24 Complejo Hospitalario Universitario de Albacete
25 Universidad de Huelva
26 Galdakao Hospital
27 Irset - Institut de recherche en santé, environnement et travail
28 EHESP - École des Hautes Études en Santé Publique [EHESP]
29 Monash University [Melbourne]

Résumé

Background: While the adverse effects of short-term ambient ozone exposure on lung function are well-documented, the impact of long-term exposure remains poorly understood, especially in adults. Methods: We aimed to investigate the association between long-term ozone exposure and lung function decline. The 3014 participants were drawn from 17 centers across eight countries, all of which were from the European Community Respiratory Health Survey (ECRHS). Spirometry was conducted to measure pre-bronchodilation forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) at approximately 35, 44, and 55 years of age. We assigned annual mean values of daily maximum running 8-h average ozone concentrations to individual residential addresses. Adjustments were made for PM2.5, NO2, and greenness. To capture the ozone-related change in spirometric parameters, our linear mixed effects regression models included an interaction term between long-term ozone exposure and age. Findings: Mean ambient ozone concentrations were approximately 65 μg/m³. A one interquartile range increase of 7 μg/m³ in ozone was associated with a faster decline in FEV1 of -2.08 mL/year (95% confidence interval: -2.79, -1.36) and in FVC of -2.86 mL/year (-3.73, -1.99) mL/year over the study period. Associations were robust after adjusting for PM2.5, NO2, and greenness. The associations were more pronounced in residents of northern Europe and individuals who were older at baseline. No consistent associations were detected with the FEV1/FVC ratio. Interpretation: Long-term exposure to elevated ambient ozone concentrations was associated with a faster decline of spirometric lung function among middle-aged European adults over a 20-year period.
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hal-04228665 , version 1 (29-05-2024)

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Tianyu Zhao, Iana Markevych, Elaine Fuertes, Kees de Hoogh, Simone Accordini, et al.. Impact of long-term exposure to ambient ozone on lung function over a course of 20 years (The ECRHS study): a prospective cohort study in adults. The Lancet Regional Health - Europe, 2023, 34, pp.100729. ⟨10.1016/j.lanepe.2023.100729⟩. ⟨hal-04228665⟩
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