Stabilisation of the RirA [4Fe–4S] cluster results in loss of iron-sensing function - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Chemical Science Année : 2023

Stabilisation of the RirA [4Fe–4S] cluster results in loss of iron-sensing function

Résumé

The regulator RirA senses Fe through its [4Fe–4S] cluster, which may have only three Cys ligands from the protein. Addition of a likely fourth Asp ligand stabilised the cluster, rendering it unable to sense Fe and locked into its DNA-binding state.

Dates et versions

hal-04225783 , version 1 (03-10-2023)

Identifiants

Citer

Elizabeth Gray, Melissa Stewart, Libby Hanwell, Jason Crack, Rebecca Devine, et al.. Stabilisation of the RirA [4Fe–4S] cluster results in loss of iron-sensing function. Chemical Science, 2023, 14 (36), pp.9744-9758. ⟨10.1039/d3sc03020b⟩. ⟨hal-04225783⟩
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