Limbic Stimulation Drives Mania in STN-DBS in Parkinson Disease: A Prospective Study - Archive ouverte HAL Access content directly
Journal Articles Annals of Neurology Year : 2022

Limbic Stimulation Drives Mania in STN-DBS in Parkinson Disease: A Prospective Study

Stéphane Prange
Zhengyu Lin
  • Function : Author
Mikail Nourredine
Teodor Danaila
  • Function : Author
Chloé Laurencin
Ouhaid Lagha-Boukbiza
  • Function : Author
Hélène Klinger
  • Function : Author
Clelie Phillipps
  • Function : Author
Gustavo Polo
  • Function : Author
Emile Simon
  • Function : Author
Patrick Mertens
Anne-Sophie Rolland
  • Function : Author
David Devos
Elise Metereau
Stéphane Thobois
  • Function : Author
  • PersonId : 900551

Abstract

In this one-year prospective study, Parkinson's disease (PD) patients with or without mania following STN-DBS were compared to investigate risk and etiological factors, clinical management and consequences. Eighteen (16.2%) out of 111 consecutive PD patients developed mania, of whom 17 were males. No preoperative risk factor was identified. Postoperative mania was related to ventral limbic subthalamic stimulation in 15 (83%) patients, and resolved as stimulation was relocated to the sensorimotor STN, besides discontinuation or reduction of dopamine agonists and use of low-dose clozapine in 12 patients, while motor and nonmotor outcomes were similar. These findings underpin the prominent role of limbic subthalamic stimulation in postoperative mania. ANN NEUROL 2022;92:411-417.
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hal-04222081 , version 1 (28-09-2023)

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Stéphane Prange, Zhengyu Lin, Mikail Nourredine, Teodor Danaila, Chloé Laurencin, et al.. Limbic Stimulation Drives Mania in STN-DBS in Parkinson Disease: A Prospective Study. Annals of Neurology, 2022, 92 (3), pp.411-417. ⟨10.1002/ana.26434⟩. ⟨hal-04222081⟩
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