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Article Dans Une Revue iScience Année : 2023

Genetic and functional odorant receptor variation in the Homo lineage

Résumé

Using ancient DNA sequences, we explored the function of olfactory receptor genes in the genus Homo. Humans, Neandertals, and Denisovans independently adapted to a wide range of geographic environments and the odours produced by their food. Variations in their odorant receptor protein sequence and structure resulted in variation in detection and perception. Studying thirty olfactory receptor genes, we found our relatives showed highly conserved receptor structures, but Homo sapiens did not. Variants led to changes in sensitivity to some odors, but no change in specificity, indicating a common olfactory repertoire in our genus. Diversity of geographic adaptations in H. sapiens may have produced greater functional variation in our lineage, increasing our olfactory repertoire and expanding our adaptive capacity.
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hal-04220813 , version 1 (28-09-2023)

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Claire A de March, Hiroaki Matsunami, Masashi Abe, Matthew Cobb, Kara C Hoover. Genetic and functional odorant receptor variation in the Homo lineage. iScience, 2023, 26 (1), pp.105908. ⟨10.1016/j.isci.2022.105908⟩. ⟨hal-04220813⟩
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