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Article Dans Une Revue Journal of Cell Signaling Année : 2017

Expression and Role of T-type Calcium Channels during Neuroendocrine Differentiation

Résumé

Neuroendocrine cells release their secretion into the extracellular environment through calcium-dependent signalling pathways. These cells share common morphological and molecular features such as the expression of specific biomarkers, neurite outgrowth and dense core secretory granules. In order to elucidate the signalling pathways leading from undifferentiated to differentiated neuroendocrine cells, the role of voltage-dependent calcium channels, central actors in the excitation-secretion coupling, has been comprehensively investigated. T-type calcium channels appear to belong to the most important ion channel family involved in the neuroendocrine differentiation process. They could also participate in the development of neuroendocrine tumours.

Dates et versions

hal-04216587 , version 1 (25-09-2023)

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Marine Warnier, Florian Gackiere, Morad Roudbaraki, Pascal Mariot. Expression and Role of T-type Calcium Channels during Neuroendocrine Differentiation. Journal of Cell Signaling, 2017, 01 (02), ⟨10.4172/2576-1471.1000113⟩. ⟨hal-04216587⟩
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