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Article Dans Une Revue Hepatology Année : 2023

Lean individuals with NAFLD have more severe liver disease and poorer clinical outcomes (NASH-CO Study)

Oumarou Nabi
  • Fonction : Auteur
Nathanaël Lapidus
  • Fonction : Auteur
Victor de Ledinghen
  • Fonction : Auteur
Jean-Michel Petit
  • Fonction : Auteur
Sofiane Kab
  • Fonction : Auteur
Adeline Renuy
  • Fonction : Auteur
Marie Zins
  • Fonction : Auteur
Karine Lacombe
  • Fonction : Auteur
Lawrence Serfaty
  • Fonction : Auteur

Résumé

Approximately 30% of the worldwide population has at least one risk factor for liver disease. Identifying advanced liver disease before the occurrence of complications remains a difficult challenge in clinical practice, where diagnosis comes too late for many patients, at the time of liver decompensation or palliative hepatocellular carcinoma, with poor short-term prognosis. Noninvasive, blood- or elastography-based tests of liver fibrosis (NITs) have been developed for the early diagnosis of advanced liver fibrosis. Recent population-based studies evaluating the screening of liver fibrosis with these NITs have provided important information on at-risk groups that should be targeted. New measures based on the sequential use of NITs help to better organize the referral of at-risk patients to the liver specialist. However, energizing these measures will require increased awareness of both chronic liver diseases and the use of NITs among non-specialists.
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Dates et versions

hal-04215101 , version 1 (22-09-2023)

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Citer

Oumarou Nabi, Nathanaël Lapidus, Jérôme Boursier, Victor de Ledinghen, Jean-Michel Petit, et al.. Lean individuals with NAFLD have more severe liver disease and poorer clinical outcomes (NASH-CO Study). Hepatology, 2023, 78 (1), pp.272-283. ⟨10.1097/HEP.0000000000000329⟩. ⟨hal-04215101⟩

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