The Gonadotropin-Releasing Hormone Associated Peptide Reduces Calcium Entry in Prolactin-Secreting Cells* - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Endocrinology Année : 1991

The Gonadotropin-Releasing Hormone Associated Peptide Reduces Calcium Entry in Prolactin-Secreting Cells*

Résumé

The precursor molecule to the GnRH contains a peptide named GnRH-associated peptide (GAP) with PRL-inhibiting properties. In this work, we have studied the electrophysiological properties and responses to GAP of three different types of PRL-secreting cells: 1) the rat tumor cell line GH3, 2) normal rat pituitary cells in primary culture, and 3) human PRL-secreting adenoma cells. Using different but complementary techniques we show that GAP reduces intracellular Ca++ levels, [Ca++]i, and inhibits Ca++ transients in these cells. This reduction of [Ca++]i results from coordinate actions of GAP on K+ and Ca++ conductances and may explain the inhibitory effect of GAP on hormonal secretion by PRL-secreting cells.
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hal-04212624 , version 1 (20-09-2023)

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P. Vacher, P.H. Seeburg, Pascal Mariot, L. Dufy-Barbe, K. Nikolics, et al.. The Gonadotropin-Releasing Hormone Associated Peptide Reduces Calcium Entry in Prolactin-Secreting Cells*. Endocrinology, 1991, 128 (1), pp.285-294. ⟨10.1210/endo-128-1-285⟩. ⟨hal-04212624⟩
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