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Article Dans Une Revue Cancers Année : 2021

Exploring the Complementarity of Pancreatic Ductal Adenocarcinoma Preclinical Models

Odile Gayet
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  • PersonId : 1285191
Rémy Nicolle
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Emilie Sohier
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  • PersonId : 1285194
Laurie Tonon
Pauline Wajda
Sandrine Boyault
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Valéry Attignon
Séverine Tabone-Eglinger
Sandrine Barbier
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Caroline Mignard
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  • PersonId : 1285198
Olivier Duchamp
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Résumé

significant association between PDX and XDPO for the chemosensitivity-associated pathways and PDX and XDPCC for the chemoresistance-associated pathways. Conclusions: Each PDAC preclinical model possesses a unique basal-like/classical transcriptomic phenotype that strongly influences their global chemosensitivity. Each preclinical model is imperfect but complementary, suggesting that a more representative approach of the clinical reality could be obtained by combining them. Translational Relevance: The identification of molecular signatures that underpin drug sensitivity to chemotherapy in PDAC remains clinically challenging. Importantly, the vast majority of studies using preclinical in vivo and in vitro models fail when transferred to patients in a clinical setting despite initially promising results. This study presents for the first time a comparison between three preclinical models directly derived from the same patients. We show that their applicability to preclinical studies should be considered with a complementary focus, avoiding tumor-based direct extrapolations, which might generate misleading conclusions and consequently the overlook of clinically relevant features.
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Dates et versions

hal-04210691 , version 1 (19-09-2023)

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Owen Hoare, Nicolas Fraunhoffer, Abdessamad Elkaoutari, Odile Gayet, Martin Bigonnet, et al.. Exploring the Complementarity of Pancreatic Ductal Adenocarcinoma Preclinical Models. Cancers, 2021, 13, ⟨10.3390/cancers13102473⟩. ⟨hal-04210691⟩

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