Rhodium(II)‐Catalyzed Selective C(sp 3 )−H Amination of Alkanes - Archive ouverte HAL
Article Dans Une Revue European Journal of Organic Chemistry Année : 2023

Rhodium(II)‐Catalyzed Selective C(sp 3 )−H Amination of Alkanes

Résumé

Abstract The development of an efficient catalytic system enabling the conversion of alkanes to valuable nitrogen‐containing building blocks is reported. Light alkanes can be selectively functionalized by an intermolecular C(sp 3 )−H amination reaction that proceeds at room temperature in the presence of only 1 mol % of a dirhodium(II) complex. Selective amination of tertiary C(sp 3 )−H within acyclic or cyclic alkanes used as limiting components leads to the corresponding amides isolated with yields in the 51–96 % range. The reaction, that can be performed on a gram‐scale, applies with equal levels of efficiency and selectivity to more complex hydrocarbons.
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Dates et versions

hal-04209991 , version 1 (18-09-2023)

Identifiants

Citer

Vincent Boquet, Junio A Guimaraes Naves, Erwan A Brunard, Ali Nasrallah, Mylène Joigneaux, et al.. Rhodium(II)‐Catalyzed Selective C(sp 3 )−H Amination of Alkanes. European Journal of Organic Chemistry, 2023, 26 (32), ⟨10.1002/ejoc.202300352⟩. ⟨hal-04209991⟩
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