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Article Dans Une Revue FEBS Letters Année : 2023

Succinate oxidation rescues mitochondrial ATP synthesis at high temperature in Drosophila melanogaster

Résumé

Decreased NADH‐induced and increased reduced FADH 2 ‐induced respiration rates at high temperatures are associated with thermal tolerance in Drosophila . Here, we determined whether this change was associated with adjustments of adenosine triphosphate (ATP) production rate and coupling efficiency (ATP/O) in Drosophila melanogaster . We show that decreased pyruvate + malate oxidation at 35°C is associated with a collapse of ATP synthesis and a drop in ATP/O ratio. However, adding succinate triggered a full compensation of both oxygen consumption and ATP synthesis rates at this high temperature. Addition of glycerol‐3‐phosphate (G3P) led to a huge increase in respiration with no further advantage in terms of ATP production. We conclude that succinate is the only alternative substrate able to compensate both oxygen consumption and ATP production rates during oxidative phosphorylation at high temperature, which has important implications for thermal adaptation.
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Dates et versions

hal-04209706 , version 1 (22-02-2024)

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Damien Roussel, Sonia Janillon, Loïc Teulier, Nicolas Pichaud. Succinate oxidation rescues mitochondrial ATP synthesis at high temperature in Drosophila melanogaster. FEBS Letters, 2023, 597 (17), pp.2221-2229. ⟨10.1002/1873-3468.14701⟩. ⟨hal-04209706⟩
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