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Article Dans Une Revue Arteriosclerosis, Thrombosis, and Vascular Biology Année : 2007

Cholesterol Accumulation Is Increased in Macrophages of Phospholipid Transfer Protein-Deficient Mice

Résumé

Objective-Phospholipid transfer protein (PLTP) is a multifunctional, extracellular lipid transport protein that plays a major role in lipoprotein metabolism and atherosclerosis. Recent in vivo studies suggested that unlike systemic PLTP, macrophage-derived PLTP would be antiatherogenic. The present study aimed at characterizing the atheroprotective properties of macrophage-derived PLTP. Methods and Results-Peritoneal macrophages were isolated from PLTP-deficient and wild-type mice and their biochemical characteristics were compared. It is shown that macrophages isolated from PLTP-deficient mice have increased basal cholesterol content and accumulate more cholesterol in the presence of LDL compared with wild-type cells. Cholesterol parameters in macrophages of PLTP-deficient mice were normalized by dietary ␣-tocopherol supplementation. Conclusions-The antiatherogenic properties of macrophage-derived PLTP are related at least in part to its ability to reduce cholesterol accumulation in macrophages through changes in the alpha-tocopherol content and oxidative status of the cells.
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hal-04200513 , version 1 (08-09-2023)

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Nicolas Ogier, Alexis Klein, Valérie Deckert, Anne Athias, Ginette Bessède, et al.. Cholesterol Accumulation Is Increased in Macrophages of Phospholipid Transfer Protein-Deficient Mice. Arteriosclerosis, Thrombosis, and Vascular Biology, 2007, 27, pp.2407 - 2412. ⟨10.1161/atvbaha.107.151753⟩. ⟨hal-04200513⟩
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