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Article Dans Une Revue Science Année : 2021

Complement factor C1q mediates sleep spindle loss and epileptic spikes after mild brain injury

Stephanie Holden
Oumaima Aboubakr
Bryan Higashikubo
  • Fonction : Auteur
Frances Cho
Andrew Chang
Alejandro Osorio Forero
Allison Morningstar
Vidhu Mathur
  • Fonction : Auteur
Logan Kuhn
Poojan Suri
  • Fonction : Auteur
Sethu Sankaranarayanan
Yaisa Andrews-Zwilling
  • Fonction : Auteur
Andrea Tenner
Anita Luthi
M. Ryan Corces
Ted Yednock

Résumé

Neuroinflammation after brain injury Traumatic brain injury affects millions of people every year and is a major cause of disability worldwide. Most of the maladaptive outcomes develop months or years later and are thought to be caused by secondary injuries that are indirect and long-term effects after the initial impact. Holden et al . found that secondary and chronic neuroinflammation and neurodegeneration are caused by the C1q molecule, a mediator of the complement pathway. C1q is responsible for chronic inflammation and secondary neuronal loss specifically in the cortico-thalamo-cortical circuit. Traumatic brain injury also leads to altered brain states that are caused by the C1q complement pathway. —PRS

Dates et versions

hal-04198976 , version 1 (07-09-2023)

Identifiants

Citer

Stephanie Holden, Fiorella Grandi, Oumaima Aboubakr, Bryan Higashikubo, Frances Cho, et al.. Complement factor C1q mediates sleep spindle loss and epileptic spikes after mild brain injury. Science, 2021, 373 (6560), ⟨10.1126/science.abj2685⟩. ⟨hal-04198976⟩
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