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Article Dans Une Revue Blood Année : 2005

TNF-related apoptosis-inducing ligand (TRAIL) in HIV-1-infected patients and its in vitro production by antigen-presenting cells

Adriano Boasso
  • Fonction : Auteur
Jean-Charles Grivel
  • Fonction : Auteur
Andrew Hardy
  • Fonction : Auteur
Stephanie Anderson
  • Fonction : Auteur
Matthew Dolan
  • Fonction : Auteur
Claire Chougnet
  • Fonction : Auteur
Jeffrey Lifson
  • Fonction : Auteur

Résumé

There is now considerable in vitro evidence that tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is involved in HIV-1 pathogenesis by inducing CD4+ T-cell death characteristic of AIDS. Therefore, we have tested levels of TRAIL in plasma samples from 107 HIV-1-infected and 53 uninfected controls as well as in longitudinal plasma samples from patients who started antiretroviral therapy (ART). TRAIL was elevated in plasma of HIV-1-infected patients compared with uninfected individuals, and patients receiving ART showed decreased plasma TRAIL levels that correlated with reduction in viral load. In vitro exposure to infectious and noninfectious HIV-1 induced TRAIL in monocytes and marginally in dendritic cells (DCs) but not in macrophages or T cells. Interestingly, the HIV-1 entry inhibitor, soluble CD4, blocked HIV-1-induced production of TRAIL. Furthermore, production and gene expression of TRAIL by monocytes were regulated by type I interferon via signal transducer and activator of transcription-1 (STAT1)/STAT2 signaling molecule. Ex vivo HIV-1 infection of human tonsil lymphoid tissue also resulted in increased TRAIL production. We demonstrate here that plasma TRAIL is elevated in HIV-1-infected patients and is decreased by ART therapy. The high production of TRAIL by antigen-presenting cells may contribute to the death of CD4+ T cells during progression to AIDS.

Dates et versions

hal-04198864 , version 1 (07-09-2023)

Identifiants

Citer

Jean-Philippe Herbeuval, Adriano Boasso, Jean-Charles Grivel, Andrew Hardy, Stephanie Anderson, et al.. TNF-related apoptosis-inducing ligand (TRAIL) in HIV-1-infected patients and its in vitro production by antigen-presenting cells. Blood, 2005, 105 (6), pp.2458-2464. ⟨10.1182/blood-2004-08-3058⟩. ⟨hal-04198864⟩
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