Algal toxins in the environment are known to accumulate up the food chain via dietary pathways, often with little apparent effect on the health of the accumulating organism. Several laboratory studies on bivalves, however, have found that exposure to toxic dinoflagellates may alter important processes such as clearance rates or oxygen consumption. Neurotoxins produced by some of these algae have also been shown to act on ion channels in fish. These behavioral or physiological effects may, in turn, alter species responses to concurrent stressors in the environment, such as variable temperatures or salinity, or the presence of other contaminants (e.g. metals) often co-occurring with biotoxins in coastal waters. Experimental food chains involving toxic dinoflagellates provide a model to assess interactions of toxin exposure with other environmental factors or contaminants in marine organisms. In this example, we examined the trophic transfer of brevetoxins (PbTxs) in a Karenia brevis-Mytilus edulis (blue mussel)- Scophthalmus maximus (turbot) food chain with simultaneous exposure to metals (combinations of radioisotopes 65Zn, 54Mn, 109Cd and 57Co). This model allowed us to examine accumulation-depuration processes of PbTxs along the food web as well as how accumulated PbTxs affected metal uptake and assimilation. We found that after 4 days feeding with 980 ± 20 cells Karenia brevis mL-1, mussels had accumulated 0.49 ± 0.22 μg PbTx eq g-1 wet wt in their soft tissues. Despite high toxin retention (78% remaining after 23 d depuration during metals exposure), PbTx exposure did not affect the assimilation of metals in mussels, excepting for small but significant increases in rates of 109Cd uptake. Turbot appeared to depurate dietary PbTxs more efficiently than mussels, as fish fed once with PbTx-containing mussel tissue contained similar concentrations of toxin in their viscera to those fed 15 times over 3 weeks. Similarly to mussels, assimilation of metals (65Zn and 54Mn) in turbot showed no influence of PbTx exposure. These results indicate that, despite the effects of PbTxs on ion-transport processes, dietary PbTx exposure may not strongly alter metal kinetics in bivalves or fish. Yet, PbTx doses and accumulated concentrations were low compared to what can be found in nature; moreover, the diverse group of algal toxins have numerous modes of action. This laboratory model provides a useful means for further investigation of interactions between biotoxins and contaminants along the food web