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Article Dans Une Revue Le Studium Multidisciplinary Journal Année : 2020

Development of novel chemoselective ligation techniques for protein chemical synthesis

Résumé

A novel strategy has been devised that allows a ligation of of thioacids and imidazolyl urea activated amines under aqueous conditions. This approach enables the traceless removal of imidazole and CO2 to directly generate the desired amide bond without affecting the side chain reactive side chain functional groups on the peptide chain. Meanwhile, the novel synthesis of peptide thioacid is also reported.
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Dates et versions

hal-04197110 , version 1 (05-09-2023)

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Thimmalapura M Vishwanatha, Vincent Aucagne. Development of novel chemoselective ligation techniques for protein chemical synthesis. Le Studium Multidisciplinary Journal, 2020, 4, pp.41 - 63. ⟨10.34846/le-studium.190.02.fr.05-2020⟩. ⟨hal-04197110⟩
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