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Article Dans Une Revue Science Advances Année : 2023

Cosegregation of recombinant chromatids maintains genome-wide heterozygosity in an asexual nematode

Résumé

In asexual animals, female meiosis is modified to produce diploid oocytes. If meiosis still involves recombination, this is expected to lead to a rapid loss of heterozygosity, with adverse effects on fitness. Many asexuals, however, have a heterozygous genome, the underlying mechanisms being most often unknown. Cytological and population genomic analyses in the nematode Mesorhabditis belari revealed another case of recombining asexual being highly heterozygous genome-wide. We demonstrated that heterozygosity is maintained despite recombination because the recombinant chromatids of each chromosome pair cosegregate during the unique meiotic division. A theoretical model confirmed that this segregation bias is necessary to account for the observed pattern and likely to evolve under a wide range of conditions. Our study uncovers an unexpected type of non-Mendelian genetic inheritance involving cosegregation of recombinant chromatids.
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hal-04196295 , version 1 (07-09-2023)

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Paternité - Pas d'utilisation commerciale

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Caroline Blanc, Nathanaëlle Saclier, Ehouarn Le Faou, Lucas Marie-Orleach, Eva Wenger, et al.. Cosegregation of recombinant chromatids maintains genome-wide heterozygosity in an asexual nematode. Science Advances , 2023, 9 (34), pp.eadi2804. ⟨10.1126/sciadv.adi2804⟩. ⟨hal-04196295⟩
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