Regiospecific Reduction of 4,6-Dinitrobenzimidazoles: Synthesis, Characterization, and Biological Evaluation - Archive ouverte HAL Access content directly
Journal Articles Chemistry and Biodiversity Year : 2023

Regiospecific Reduction of 4,6-Dinitrobenzimidazoles: Synthesis, Characterization, and Biological Evaluation

Abstract

The regiospecific reduction of 4,6-dinitrobenzimidazole derivatives leading to the corresponding 4-amino-6-nitrobenzimidazoles was studied. The identification of the formed product structures was accomplished by spectroscopic and X-ray diffraction data. The anticancer and antiparasitic activities of the synthesized compounds were examined, and promising activities against Toxoplasma gondii and Leishmania major parasites were discovered for certain 4,6-dinitrobenzimidazoles in addition to moderate anticancer activities of the 4-amino-6-nitrobenzimidazole derivatives against T. gondii cells. However, the tumor cell experiments revealed a promising sensitivity of p53-negative colon cancer cells to these compounds. © 2023 The Authors. Chemistry and Biodiversity published by Wiley-VHCA AG, Zurich, Switzerland.
No file

Dates and versions

hal-04195347 , version 1 (04-09-2023)

Identifiers

Cite

El Alami Abouelhaoul, Abdellatif El Kihel, Mustapha Ahbala, Hamid Sdassi, Leonhard H. F. Köhler, et al.. Regiospecific Reduction of 4,6-Dinitrobenzimidazoles: Synthesis, Characterization, and Biological Evaluation. Chemistry and Biodiversity, 2023, 20 (7), pp.e202300191. ⟨10.1002/cbdv.202300191⟩. ⟨hal-04195347⟩
8 View
0 Download

Altmetric

Share

Gmail Facebook X LinkedIn More