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Article Dans Une Revue Molecular Psychiatry Année : 2023

The risk of hospitalization for psychotic disorders following hospitalization for COVID-19: a French nationwide longitudinal study

Baptiste Pignon
  • Fonction : Auteur
Valentina Decio
  • Fonction : Auteur
Philippe Pirard
  • Fonction : Auteur
Olivier Bouaziz
  • Fonction : Auteur
P. A. Geoffroy
Viviane Kovess-Masfety
Marion Leboyer
  • Fonction : Auteur
Vittorio Perduca
Franck Schürhoff
  • Fonction : Auteur
Nolwenn Regnault
  • Fonction : Auteur
Sarah Tebeka

Résumé

COVID-19, like other infectious diseases, may be a risk factor for psychotic disorders. We aimed to compare the proportions of hospitalizations for psychotic disorders in the 12 months following discharge from hospital for either COVID-19 or for another reason in the adult general population in France during the first wave of the pandemic. We conducted a retrospective longitudinal nationwide study using the national French administrative healthcare database. Psychotic disorders were first studied as a whole, and then chronic and acute disorders separately. The role of several adjustment factors, including sociodemographics, a history of psychotic disorder, the duration of the initial hospitalization, and the level of care received during that hospitalization, were also analyzed. Between 1 January 2020 and 30 June 2020, a total of 14,622 patients were hospitalized for psychotic disorders in the 12 months following discharge from hospital for either COVID-19 or another reason. Initial hospitalization for COVID-19 (vs. another reason) was associated with a lower rate of subsequent hospitalization for psychotic disorders (0.31% vs. 0.51%, odds ratio (OR) = 0.60, 95% confidence interval (CI) [0.53-0.67]). This was true for both chronic and acute disorders, even after adjusting for the various study variables. Importantly, a history of psychotic disorder was a major determinant of hospitalization for psychotic disorders (adjusted OR = 126.56, 95% CI [121.85-131.46]). Our results suggest that, in comparison to individuals initially hospitalized for another reason, individuals initially hospitalized for COVID-19 present a lower risk of hospitalization for first episodes of psychotic symptoms/disorders or for psychotic relapse in the 12 months following discharge. This finding contradicts the hypothesis that there is a higher risk of psychotic disorders after a severe COVID-19.
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hal-04195169 , version 1 (21-09-2023)

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Baptiste Pignon, Valentina Decio, Philippe Pirard, Olivier Bouaziz, Emmanuelle Corruble, et al.. The risk of hospitalization for psychotic disorders following hospitalization for COVID-19: a French nationwide longitudinal study. Molecular Psychiatry, 2023, ⟨10.1038/s41380-023-02207-8⟩. ⟨hal-04195169⟩
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