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Article Dans Une Revue British Journal of Cancer Année : 2023

Radiation exposure and leukaemia risk among cohorts of persons exposed to low and moderate doses of external ionising radiation in childhood

Mark P. Little
  • Fonction : Auteur
Richard Wakeford
Lydia B. Zablotska
  • Fonction : Auteur
David Borrego
  • Fonction : Auteur
Keith T. Griffin
  • Fonction : Auteur
Choonsik Lee
  • Fonction : Auteur
Alina V. Brenner
  • Fonction : Auteur
Jeremy S. Miller
  • Fonction : Auteur
David S. Campbell
  • Fonction : Auteur
Mark S. Pearce
  • Fonction : Auteur
Siegal Sadetzki
  • Fonction : Auteur
Michele Morin Doody
  • Fonction : Auteur
Erik C.V. Holmberg
Marie Lundell
  • Fonction : Auteur
Benjamin C. French
  • Fonction : Auteur
Michael Jacob Adams
Amy Berrington de González
  • Fonction : Auteur
Martha S. Linet
  • Fonction : Auteur

Résumé

Background: Many high-dose groups demonstrate increased leukaemia risks, with risk greatest following childhood exposure; risks at low/moderate doses are less clear. Methods: We conducted a pooled analysis of the major radiation-associated leukaemias (acute myeloid leukaemia (AML) with/without the inclusion of myelodysplastic syndrome (MDS), chronic myeloid leukaemia (CML), acute lymphoblastic leukaemia (ALL)) in ten childhood-exposed groups, including Japanese atomic bomb survivors, four therapeutically irradiated and five diagnostically exposed cohorts, a mixture of incidence and mortality data. Relative/absolute risk Poisson regression models were fitted. Results: Of 365 cases/deaths of leukaemias excluding chronic lymphocytic leukaemia, there were 272 AML/CML/ALL among 310,905 persons (7,641,362 person-years), with mean active bone marrow (ABM) dose of 0.11 Gy (range 0–5.95). We estimated significant (P < 0.005) linear excess relative risks/Gy (ERR/Gy) for: AML (n = 140) = 1.48 (95% CI 0.59–2.85), CML (n = 61) = 1.77 (95% CI 0.38–4.50), and ALL (n = 71) = 6.65 (95% CI 2.79–14.83). There is upward curvature in the dose response for ALL and AML over the full dose range, although at lower doses (<0.5 Gy) curvature for ALL is downwards. Discussion: We found increased ERR/Gy for all major types of radiation-associated leukaemia after childhood exposure to ABM doses that were predominantly (for 99%) <1 Gy, and consistent with our prior analysis focusing on <100 mGy.

Domaines

Cancer
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Dates et versions

hal-04194842 , version 1 (04-09-2023)

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Citer

Mark P. Little, Richard Wakeford, Lydia B. Zablotska, David Borrego, Keith T. Griffin, et al.. Radiation exposure and leukaemia risk among cohorts of persons exposed to low and moderate doses of external ionising radiation in childhood. British Journal of Cancer, 2023, ⟨10.1038/s41416-023-02387-8⟩. ⟨hal-04194842⟩
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