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Article Dans Une Revue The Lancet Digital Health Année : 2023

Development and validation of an electronic daily control score for asthma (e-DASTHMA): a real-world direct patient data study

Bernardo Sousa-Pinto , Cristina Isabel Oliveira Jácome , Ana Margarida Pereira , Frederico Soares Regateiro , Rute Alexandra Borges Almeida , Wienczyslawa Czarlewski , Marek Kulus , Mohamed H. Shamji , Louis Philippe Boulet , Matteo Bonini , Luisa Brussino , Walter G. Canonica , Álvaro Augusto Cruz , Bilun Gemicioglu , Tari M.K. Haahtela , Maciej Kupczyk , Violeta Kvedariene , Désirée E.S. Larenas-Linnemann , Renaud E. Louis , Marek B. Niedoszytko , Nhân Pham-Thi , Francesca A. Puggioni , Jan Romantowski , Joaquín Sastre , Nicola Scichilone , Luís Manuel Taborda-Barata , M. T. Ventura , Rafael José Vieira , Ioana O. Agache , Anna Bedbrook , Karl Christian Bergmann , R. Amaral , Luís F. Azevedo , Sinthia Zrinka Bosnic-Anticevich , Guy G.O. Brusselle , Roland Otto Buhl , Lorenzo Cecchi , Denis André Charpin , Cláudia Loureiro , Frédéric J. de Blay , Stefano Renato del Giacco , Philippe Devillier (1) , Ewa Jassem , Guy F.P. Joos , Marek Jutel , Ludger Klimek , P. B. Kuna , Daniel Laune , Jorge A. Luna Pech , Mika Juhani Makela , Mário Morais-Almeida , Rachel Nadif (2) , Hugo E. Neffen , Ken Ohta , Nikolaos G. Papadopoulos , Alberto Papi , Benoît Pétré , Oliver Pfaar , Daniela Rivero Yeverino , Carlos Robalo Cordeiro , Nicolas Roche , Ana Sá-Sousa , Bolesław Krzysztof Samolinski , Aziz Sheikh , Charlotte Suppli Ulrik , Omar Sharif Usmani , Arūnas Valiulis , Olivier Vandenplas , P. Manuel Vieira-Marques , Arzu A. Yorgancioglu , Torsten Zuberbier , Josep María Anto , Joao A. Fonseca , Jean J. Bousquet
Bernardo Sousa-Pinto
Cristina Isabel Oliveira Jácome
Ana Margarida Pereira
Frederico Soares Regateiro
Rute Alexandra Borges Almeida
Wienczyslawa Czarlewski
  • Fonction : Auteur
Marek Kulus
Mohamed H. Shamji
Louis Philippe Boulet
  • Fonction : Auteur
Matteo Bonini
Luisa Brussino
Walter G. Canonica
Álvaro Augusto Cruz
  • Fonction : Auteur
Bilun Gemicioglu
Tari M.K. Haahtela
  • Fonction : Auteur
Maciej Kupczyk
Violeta Kvedariene
Désirée E.S. Larenas-Linnemann
Renaud E. Louis
  • Fonction : Auteur
Marek B. Niedoszytko
Nhân Pham-Thi
  • Fonction : Auteur
Francesca A. Puggioni
Jan Romantowski
Joaquín Sastre
  • Fonction : Auteur
Nicola Scichilone
Luís Manuel Taborda-Barata
M. T. Ventura
Rafael José Vieira
Ioana O. Agache
  • Fonction : Auteur
Anna Bedbrook
  • Fonction : Auteur
Karl Christian Bergmann
  • Fonction : Auteur
R. Amaral
Luís F. Azevedo
Sinthia Zrinka Bosnic-Anticevich
Guy G.O. Brusselle
  • Fonction : Auteur
Roland Otto Buhl
  • Fonction : Auteur
Lorenzo Cecchi
Denis André Charpin
  • Fonction : Auteur
Cláudia Loureiro
  • Fonction : Auteur
Frédéric J. de Blay
  • Fonction : Auteur
Stefano Renato del Giacco
  • Fonction : Auteur
Philippe Devillier
  • Fonction : Auteur
  • PersonId : 956241
Ewa Jassem
Guy F.P. Joos
  • Fonction : Auteur
Marek Jutel
  • Fonction : Auteur
Ludger Klimek
  • Fonction : Auteur
P. B. Kuna
Daniel Laune
  • Fonction : Auteur
Jorge A. Luna Pech
Mika Juhani Makela
  • Fonction : Auteur
Mário Morais-Almeida
  • Fonction : Auteur
Hugo E. Neffen
  • Fonction : Auteur
Ken Ohta
  • Fonction : Auteur
Nikolaos G. Papadopoulos
  • Fonction : Auteur
Alberto Papi
  • Fonction : Auteur
Benoît Pétré
Oliver Pfaar
Daniela Rivero Yeverino
  • Fonction : Auteur
Carlos Robalo Cordeiro
  • Fonction : Auteur
Nicolas Roche
Ana Sá-Sousa
Bolesław Krzysztof Samolinski
  • Fonction : Auteur
Aziz Sheikh
  • Fonction : Auteur
Charlotte Suppli Ulrik
  • Fonction : Auteur
Omar Sharif Usmani
  • Fonction : Auteur
Arūnas Valiulis
  • Fonction : Auteur
Olivier Vandenplas
  • Fonction : Auteur
P. Manuel Vieira-Marques
Arzu A. Yorgancioglu
Torsten Zuberbier
  • Fonction : Auteur
Josep María Anto
Joao A. Fonseca
Jean J. Bousquet
  • Fonction : Auteur

Résumé

Background: Validated questionnaires are used to assess asthma control over the past 1–4 weeks from reporting. However, they do not adequately capture asthma control in patients with fluctuating symptoms. Using the Mobile Airways Sentinel Network for airway diseases (MASK-air) app, we developed and validated an electronic daily asthma control score (e-DASTHMA). Methods: We used MASK-air data (freely available to users in 27 countries) to develop and assess different daily control scores for asthma. Data-driven control scores were developed based on asthma symptoms reported by a visual analogue scale (VAS) and self-reported asthma medication use. We included the daily monitoring data from all MASK-air users aged 16–90 years (or older than 13 years to 90 years in countries with a lower age of digital consent) who had used the app in at least 3 different calendar months and had reported at least 1 day of asthma medication use. For each score, we assessed construct validity, test–retest reliability, responsiveness, and accuracy. We used VASs on dyspnoea and work disturbance, EQ-5D-VAS, Control of Allergic Rhinitis and Asthma Test (CARAT), CARAT asthma, and Work Productivity and Activity Impairment: Allergy Specific (WPAI:AS) questionnaires as comparators. We performed an internal validation using MASK-air data from Jan 1 to Oct 12, 2022, and an external validation using a cohort of patients with physician-diagnosed asthma (the INSPIRERS cohort) who had had their diagnosis and control (Global Initiative for Asthma [GINA] classification) of asthma ascertained by a physician. Findings: We studied 135 635 days of MASK-air data from 1662 users from May 21, 2015, to Dec 31, 2021. The scores were strongly correlated with VAS dyspnoea (Spearman correlation coefficient range 0·68–0·82) and moderately correlated with work comparators and quality-of-life-related comparators (for WPAI:AS work, we observed Spearman correlation coefficients of 0·59–0·68). They also displayed high test–retest reliability (intraclass correlation coefficients range 0·79–0·95) and moderate-to-high responsiveness (correlation coefficient range 0·69–0·79; effect size measures range 0·57–0·99 in the comparison with VAS dyspnoea). The best-performing score displayed a strong correlation with the effect of asthma on work and school activities in the INSPIRERS cohort (Spearman correlation coefficients 0·70; 95% CI 0·61–0·78) and good accuracy for the identification of patients with uncontrolled or partly controlled asthma according to GINA (area under the receiver operating curve 0·73; 95% CI 0·68–0·78). Interpretation: e-DASTHMA is a good tool for the daily assessment of asthma control. This tool can be used as an endpoint in clinical trials as well as in clinical practice to assess fluctuations in asthma control and guide treatment optimisation. Funding: None.
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Dates et versions

hal-04193721 , version 1 (19-12-2023)

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Bernardo Sousa-Pinto, Cristina Isabel Oliveira Jácome, Ana Margarida Pereira, Frederico Soares Regateiro, Rute Alexandra Borges Almeida, et al.. Development and validation of an electronic daily control score for asthma (e-DASTHMA): a real-world direct patient data study. The Lancet Digital Health, 2023, 5 (4), pp.e227-e238. ⟨10.1016/S2589-7500(23)00020-1⟩. ⟨hal-04193721⟩
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