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Article Dans Une Revue (Article De Synthèse) Frontiers in Cellular Neuroscience Année : 2023

Axo-axonic cells in neuropsychiatric disorders: a systematic review

Résumé

Imbalance between excitation and inhibition in the cerebral cortex is one of the main theories in neuropsychiatric disorder pathophysiology. Cortical inhibition is finely regulated by a variety of highly specialized GABAergic interneuron types, which are thought to organize neural network activities. Among interneurons, axo-axonic cells are unique in making synapses with the axon initial segment of pyramidal neurons. Alterations of axo-axonic cells have been proposed to be implicated in disorders including epilepsy, schizophrenia and autism spectrum disorder. However, evidence for the alteration of axo-axonic cells in disease has only been examined in narrative reviews. By performing a systematic review of studies investigating axo-axonic cells and axo-axonic communication in epilepsy, schizophrenia and autism spectrum disorder, we outline convergent findings and discrepancies in the literature. Overall, the implication of axo-axonic cells in neuropsychiatric disorders might have been overstated. Additional work is needed to assess initial, mostly indirect findings, and to unravel how defects in axo-axonic cells translates to cortical dysregulation and, in turn, to pathological states.
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hal-04193177 , version 1 (13-09-2023)

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Juliette Vivien, Anass El Azraoui, Cloé Lheraux, Frederic Lanore, Bruno Aouizerate, et al.. Axo-axonic cells in neuropsychiatric disorders: a systematic review. Frontiers in Cellular Neuroscience, 2023, 17, pp.1212202. ⟨10.3389/fncel.2023.1212202⟩. ⟨hal-04193177⟩
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