Confinement of the antitumoral drug cisplatin inside edge-functionalized carbon nanotubes and its release near lipid membrane - Archive ouverte HAL Access content directly
Journal Articles The European Physical Journal D : Atomic, molecular, optical and plasma physics Year : 2021

Confinement of the antitumoral drug cisplatin inside edge-functionalized carbon nanotubes and its release near lipid membrane

Abstract

Platinum complexes are active anti-tumor agents. They are widely used in chemotherapy medication for the treatment of several cancer types. Unfortunately, these drugs present poor stability when administered and have several side effects, damaging healthy cells around the tumor. One way to remedy the damage is to confine drug molecules in carbon cages such as carbon nanotubes (CNTs) before delivering them near their target cells. In order to open their ends, the CNTs must be functionnalized by oxidation. This leads to the saturation of the carbon dangling bonds with an alcohol functional group, for instance. In this study, molecular dynamics simulations are carried out to assess the influence of CNT's chemical functional groups (-H,-OH,-COOH) on the retention time and release processes of cisplatin molecules throughout the process of vectorization to a cell membrane.
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Dates and versions

hal-04189061 , version 1 (28-08-2023)

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Alia Mejri, Bahoueddine Tangour, Guillaume Herlem, Fabien Picaud. Confinement of the antitumoral drug cisplatin inside edge-functionalized carbon nanotubes and its release near lipid membrane. The European Physical Journal D : Atomic, molecular, optical and plasma physics, 2021, 75 (3), pp.99. ⟨10.1140/epjd/s10053-021-00114-7⟩. ⟨hal-04189061⟩

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