Journal Articles Bulletin de l'Académie Nationale de Médecine Year : 1998

[Reproducibility and prognostic value of histopathological classifications of malignant lymphomas. Prolegomena for the 1st international classification proposed by WHO. Group of the non-Hodgkin's Malignant Lymphoma Classification Project].

J Diebold
  • Function : Author
D Weisenburger
  • Function : Author
K Maclennan
  • Function : Author
H Müller-Hermelink
  • Function : Author
B Nathwani
  • Function : Author
N Harris
  • Function : Author
J Anderson
  • Function : Author
J Armitage
  • Function : Author

Abstract

Different histopathologic classifications have been used in the study of malignant lymphomas. The clinical relevance (reproducibility, prognostic value) has not been precisely studied. The "non-Hodgkin's lymphoma classification project" has been organized to study a cohort of 1,403 cases in 9 sites around the world consisting of consecutive patients seen between 1988 and 1990 in order to have a good follow-up. The reproducibility of the up-dated Kiel and the ILSG (REAL) classifications between the 5 visiting expert hematopathologists was pretty good, at least 85% for the majority of the entities. According to survival curves, the lymphomas can be stratified in 4 different groups. Comparison with the international prognostic index demonstrate that for therapeutic strategy both histopathology and index should be used. The results bring a good support to the project of the WHO to propose the first international classification of lymphomas based on both forme classifications.
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Dates and versions

hal-04185114 , version 1 (22-08-2023)

Identifiers

  • HAL Id : hal-04185114 , version 1
  • PUBMED : 9916346

Cite

J Diebold, D Weisenburger, K Maclennan, H Müller-Hermelink, B Nathwani, et al.. [Reproducibility and prognostic value of histopathological classifications of malignant lymphomas. Prolegomena for the 1st international classification proposed by WHO. Group of the non-Hodgkin's Malignant Lymphoma Classification Project].. Bulletin de l'Académie Nationale de Médecine, 1998, 182 (7), pp.1537-48; discussion 1548-9. ⟨hal-04185114⟩

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