Are protocol graft biopsies after pediatric liver transplantation useful? Experience in a single center over 20 years - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Clinical Transplantation Année : 2023

Are protocol graft biopsies after pediatric liver transplantation useful? Experience in a single center over 20 years

Emma Wischlen
Olivier Boillot
  • Fonction : Auteur
Christine Rivet
  • Fonction : Auteur
Alain Lachaux
  • Fonction : Auteur
  • PersonId : 907892
Raymonde Bouvier
  • Fonction : Auteur
Valérie Hervieu
  • Fonction : Auteur
Jean‐yves Scoazec
  • Fonction : Auteur
Sophie Collardeau-Frachon
  • Fonction : Auteur
Jérôme Dumortier
Noémie Laverdure
  • Fonction : Auteur

Résumé

Abstract Background The role of protocol liver biopsies (PLB) in the follow‐up of pediatric liver transplant recipients remains questionable. This single‐center retrospective study aimed to evaluate their clinical impact on the long‐term management of pediatric liver transplant recipients. Methods We described histopathological lesions and clinical consequences for patient management of PLB performed 1, 5, 10, 15, 20, and 25 years after pediatric liver transplantation (LT). Results A total of 351 PLB performed on 133 patients between 1992 and 2021 were reviewed. PLB found signs of rejection in 21.7% of cases (76/351), and moderate to severe fibrosis in 26.5% of cases (93/351). Overall, 264 PLB (75.2%) did not cause any changes to patient care. Immunosuppression was enhanced after 63 PLB, including 23 cases of occult rejection. The 1‐year PLB triggered significantly more changes, while biopsies at 15, 20, and 25 years produced the lowest rates of subsequent modifications. PLB had a significantly higher probability of inducing therapeutic changes if the patient had abnormal biological or imaging results (odds ratio [OR] 2.82 and 2.06), or a recent history of rejection or bacterial infection (OR 2.22 and 2.03). Conclusion Our results suggest that, although it often does not prompt any treatment changes, PLB could be performed because of its ability to detect silent rejection requiring an increase in immunosuppression. PLB could be carried out 1, 5, and 10 years after LT and then every 10 years in patients with normal biological and imaging results and no recent complications, while other patients could be kept on a 5‐year protocol.
Fichier non déposé

Dates et versions

hal-04183832 , version 1 (21-08-2023)

Identifiants

Citer

Emma Wischlen, Olivier Boillot, Christine Rivet, Alain Lachaux, Raymonde Bouvier, et al.. Are protocol graft biopsies after pediatric liver transplantation useful? Experience in a single center over 20 years. Clinical Transplantation, 2023, 37 (2), ⟨10.1111/ctr.14898⟩. ⟨hal-04183832⟩

Collections

HCL HEH
4 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More