Muscle Atrophy: From Bench to Bedside - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue International Journal of Molecular Sciences Année : 2023

Muscle Atrophy: From Bench to Bedside

Résumé

The loss of muscle mass is a common adaptation to some physiological situations (e.g., bed rest), but also to many diseases (e.g., diabetes, cancer, heart failure, respiratory failure, renal failure and sepsis), which is due to an imbalance between protein synthesis and protein degradation [1]. Muscle loss contributes to the frailty syndrome and is associated with impaired quality of life and increased risk of death whatever the causal disease. In addition, muscle loss also decreases the efficiency of treatments, such as chemotherapy in cancer patients. Fighting against muscle loss is thus a major goal for ameliorating patients’ health. Compelling data demonstrate that increased proteolysis is often the main factor explaining muscle wasting [2]. However, muscle atrophy is a highly coordinated process that implies the concomitant regulation of anabolic and catabolic pathways, which suggests that we not restrict our studies to proteolysis. A potential strategy to improve patients’ condition is to reduce muscle wasting by regulating either proteolysis, protein synthesis or both. Interestingly, hibernating mammals are naturally resistant to muscle atrophy in conditions known to induce highly debilitating situations in humans, and more interestingly, this resistance can be transferred to other mammalian cells [3].
ijms-24-07551.pdf (178.96 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-04178463 , version 1 (08-08-2023)

Licence

Paternité

Identifiants

Citer

Daniel Taillandier. Muscle Atrophy: From Bench to Bedside. International Journal of Molecular Sciences, 2023, 24 (8), pp.7551. ⟨10.3390/ijms24087551⟩. ⟨hal-04178463⟩
21 Consultations
4 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More