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Article Dans Une Revue American Journal of Physiology. Renal Physiology Année : 1991

11 beta-Hydroxysteroid dehydrogenase mRNA expression in rat kidney

J. Yau
  • Fonction : Auteur
A. van Haarst
  • Fonction : Auteur
Marie-Pierre Moisan
S. Fleming
  • Fonction : Auteur
J. Seckl
  • Fonction : Auteur

Résumé

11 beta-Hydroxysteroid dehydrogenase (11 beta-OHSD) protects nonspecific renal mineralocorticoid receptors from exposure to circulating glucocorticoid in vivo by catalyzing the conversion of corticosterone to inactive 11-dehydrocorticosterone. Although 11 beta-OHSD bioactivity and aldosterone binding sites are found in distal tubular cells, mineralocorticoid receptor and 11 beta-OHSD immunoreactivities are not colocalized. However, there are several kidney isoforms of 11 beta-OHSD, not all of which may be immunoreactive, whereas only a single mRNA species has been described. Using in situ hybridization we found 11 beta-OHSD mRNA is highly expressed in all renal tubular epithelia in the rat. It is therefore likely that 11 beta-OHSD is colocalized with mineralocorticoid receptors in distal tubular cells.
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Dates et versions

hal-04175355 , version 1 (02-08-2023)

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Citer

J. Yau, A. van Haarst, Marie-Pierre Moisan, S. Fleming, C. Edwards, et al.. 11 beta-Hydroxysteroid dehydrogenase mRNA expression in rat kidney. American Journal of Physiology. Renal Physiology, 1991, 260 (5), pp.F764-F767. ⟨10.1152/ajprenal.1991.260.5.F764⟩. ⟨hal-04175355⟩
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