Identification and characterization of lung commensal bacteria that modulate immune response in Tuberculosis - Archive ouverte HAL Accéder directement au contenu
Communication Dans Un Congrès Année : 2019

Identification and characterization of lung commensal bacteria that modulate immune response in Tuberculosis

Aude Remot

Résumé

Tuberculosis (TB) is still one of the deadliest infectious diseases in humans. As TB disease is driven by exacerbation of the immune response, promising approaches include host-targeting therapies aiming at controlling the balance between pathogen eradication and limitation of the inflammation in order to prevent immunopathology. Such immune modulation has been observed through modification of the gut-microbiota compartment with oral administration of specific bacterial strains (i.e. probiotics) in other respiratory diseases. In TB, a dysbiosis of the microbiota is observed in patients, and microbiota perturbation in mice increases susceptibility to Mycobacterium tuberculosis (Mtb). Here, we assessed whether bacterial strains isolated from the recently described lung microbiota could have a local impact on Mtb infection by protecting against immune dysfunction for the host benefit. Through intranasal administration in mice, we identified different microbiota strains isolated from mouse lungs with a strong ability to modulate the lung T cell compartment. The same in vivo approach in Mtb-infected mice revealed one strain with a remarkable capacity to diminish Mtb infection-associated lung immunopathology, accompanied by a specific immune signature characterized by an increase level of regulatory T cells sharing surprisingly T-helper 17 cell markers. Collectively, this work may contribute to the design of host-directed therapies to reduce the destructive inflammatory response in TB, without further fomenting the occurrence of multiple-drug resistant Mtb strains. It will also shed light on poorly described populations in the lungs such as the RORgt+ Foxp3+ biTregs and their interactions with the microbiota.

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Domaines

Immunologie
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Dates et versions

hal-04171999 , version 1 (27-07-2023)

Identifiants

  • HAL Id : hal-04171999 , version 1
  • WOS : 000524982500239

Citer

Lucie Bernard-Raichon, André Colom, Margaux Cescato, Céline Cougoule, Pauline Guilloton, et al.. Identification and characterization of lung commensal bacteria that modulate immune response in Tuberculosis. 103. Annual Meeting of the American Association of Immunologists, American Association of Immunologists, May 2019, San Diego, CA, United States. ⟨hal-04171999⟩
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