Self-assembled lipid-prodrug nanoparticles for the treatment of severe diseases
Résumé
Combining the distinct advantages of the prodrug strategy with those of nanoparticulate delivery systems has demonstrated several advantages in the treatment of severe diseases such as better diffusion through biological barriers, enzymatic activation of the lipid-conjugate in the diseased area, drug protection, better pharmacokinetic and biodistribution, intracellular delivery and/or targeting properties. Thanks to fundamental advances in supramolecular chemistry and to the fine-tuning of the nature of the lipid (fatty acid, steroid, phospholipid, glyceride etc.), the drug itself (small molecule entity or macromolecule) and the drug-lipid chemical link (ester, amide, disulfide, etc.), it is now possible to develop drug-lipid conjugates capable of self-assembling spontaneously as nanoparticles in water media with unique supramolecular organizations. In other words, apart from using solvents to allow the solubilization of the molecular species, no other excipients are needed. In this review, we offer the reader a deeper understanding of the chemical synthesis, physico-chemistry, structure, and pharmacological activity of lipid-prodrug based nanomedicines and discuss the outlook for translation to clinical practice.
Domaines
ChimieOrigine | Fichiers produits par l'(les) auteur(s) |
---|