An agent-based model of vibration-induced intimal hyperplasia
Résumé
Acute exposure to hand-arm transmitted vibrations (HAVs) may decrease the wall shear stress (WSS) exerted by the blood flow on the arterial endothelium. In the case of chronic exposure to HAVs, these WSS changes can lead to arterial growth and remodeling potentially induced by an intimal hyperplasia phenomenon. Accordingly, we implemented an agent-based model (ABM) that captures the hemodynamics-driven and mechanoregulated cellular mechanisms involved in vibrationinduced intimal hyperplasia. Our ABM was combined with flow loop experiments that investigated the WSS-modulated secretion of the platelet-derived growth factor BB (PDGF-BB) by the endothelial cells. The ABM rules parameters were then identified and calibrated using our experimental findings and literature data. The model was able to replicate the basal state (no vibration) as well as predict a 30% stenosis resulting from a chronic drop of WSS values mimicking exposure to vibration during a timeframe of 10 years. The study of the influence of different WSS-modulated phenomena on the model showed that the magnitude of stenosis largely depends on the migratory effects of PDGF-BB and the mitogenic effects of
Domaines
Mécanique [physics]Origine | Fichiers produits par l'(les) auteur(s) |
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https://hal.science/hal-04153796
Soumis le : jeudi 6 juillet 2023-13:30:50
Dernière modification le : mercredi 24 avril 2024-11:14:15
Archivage à long terme le : lundi 9 octobre 2023-08:29:58
Dates et versions
Identifiants
- HAL Id : hal-04153796 , version 1
- DOI : 10.1007/s10237-022-01601-5
- PUBMED : 35852731
Citer
Maha Reda, Christophe Noël, Nicla Settembre, Jérôme Chambert, Arnaud Lejeune, et al.. An agent-based model of vibration-induced intimal hyperplasia. Biomechanics and Modeling in Mechanobiology, 2022, 21 (5), pp.1457 - 1481. ⟨10.1007/s10237-022-01601-5⟩. ⟨hal-04153796⟩
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