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Article Dans Une Revue Research Square - Preprint Année : 2023

Geo-Environmental Factors and the Effectiveness of Mulberry Leaf Extract in Managing Malaria: A Study in Purulia District, West Bengal, India

Sayantan Pradhan
  • Fonction : Auteur
Samrat Hore
  • Fonction : Auteur
Stabak Roy
  • Fonction : Auteur
Simi Manna
  • Fonction : Auteur
Paulami Dam
  • Fonction : Auteur
Rittick Mondal
  • Fonction : Auteur
Amit Ghati
  • Fonction : Auteur
Trishanjan Biswas
  • Fonction : Auteur
Supriya Sharma
  • Fonction : Auteur
Waikhom Somraj Singh
  • Fonction : Auteur
Sankarsan Roy
  • Fonction : Auteur
Aparajita Basu
  • Fonction : Auteur
Kailash Pandey
  • Fonction : Auteur
Soumadri Samanta
  • Fonction : Auteur
Kapil Vashisht
  • Fonction : Auteur
Tuphan Kanti Dolai
  • Fonction : Auteur
Pratip Kumar Kundu
  • Fonction : Auteur
Saptarshi Mitra
  • Fonction : Auteur
Amit Bikram Maity
  • Fonction : Auteur
Ikbal Agah Agah Ince

Résumé

Abstract Malaria prevalence has become medically important as well as a socioeconomic impediment for the endemic regions, including Purulia, West Bengal. Geo-environmental variables, humidity, altitude, and land use patterns are responsible for malaria. For surveillance of the endemic nature of Purulia’s blocks, statistical and spatiotemporal factors analysis have been done here. Also, a novel approach for the Pf malaria treatment using methanolic leaf extract of Morus alba S1 has significantly reduced the parasite load. The EC 50 value (1.852) of the methanolic extract of M. alba S1 with P. falciparum 3D7 strain is close to the EC 50 value (0.998) of the standard drug chloroquine with the same chloroquine-sensitive strain. Further studies with an in-silico model have shown successful interaction between DHFR and the leaf extract. Both 1-octadecyne and oxirane interacted favourably, which was depicted through GC-MS analysis. The predicted binary logistic regression model will help the policy makers for epidemiological surveillance in malaria-prone areas worldwide when substantial climate variables create a circumstance favourable for malaria. From the in vitro and in silico studies, it can be concluded that the methanolic extract of M. alba S1 leaves is promising and may play an influential role in the Pf malaria treatment in the near future.

Dates et versions

hal-04151420 , version 1 (04-07-2023)

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Citer

Sayantan Pradhan, Samrat Hore, Stabak Roy, Simi Manna, Paulami Dam, et al.. Geo-Environmental Factors and the Effectiveness of Mulberry Leaf Extract in Managing Malaria: A Study in Purulia District, West Bengal, India. Research Square - Preprint, 2023, ⟨10.21203/rs.3.rs-2962310/v1⟩. ⟨hal-04151420⟩
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