Night-Time Apomorphine Infusion: Who Are the Best Candidates?
Valérie Cochen de Cock
(1, 2)
,
Pauline Dodet
(3)
,
Smaranda Leu-Semenescu
(3)
,
Cécile Aerts
(1, 2)
,
Beatriz Abril
(4)
,
Giovanni Castelnovo
(4)
,
Nicolas Landragin
(5)
,
Sophie Drapier
(6, 7)
,
Hélène Olivet
(8)
,
Anne Gaelle Corbillé
(9, 10)
,
Laurène Leclair-Visonneau
(10, 11)
,
Mathieu Anheim
(12, 13)
,
Marie Vidailhet
(14, 3)
,
Isabelle Arnulf
(3, 14)
,
Mohamed Doulazmi
(15)
,
Emmanuel Roze
(14, 3)
1
Clinique Beau Soleil [Montpellier]
2 Euromov DHM - EuroMov - Digital Health in Motion
3 CHU Pitié-Salpêtrière [AP-HP]
4 CHU Nîmes - Centre Hospitalier Universitaire de Nîmes
5 Clinique du Millénaire - Oc Santé [Montpellier]
6 CIC - Centre d'Investigation Clinique [Rennes]
7 Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Ponchaillou]
8 Polyclinique Saint Laurent [Rennes]
9 CIC 0004 - Nantes - Centre d'investigation clinique (CIC) de Nantes -CIC Plurithématique
10 CHU Nantes - Centre Hospitalier Universitaire de Nantes = Nantes University Hospital
11 TENS - The Enteric Nervous System in gut and brain disorders [U1235]
12 CHU Strasbourg - Centre Hospitalier Universitaire [Strasbourg]
13 IGBMC - Institut de Génétique et de Biologie Moléculaire et Cellulaire
14 ICM - Institut du Cerveau = Paris Brain Institute
15 B2A-IBPS - Adaptation Biologique et Vieillissement = Biological Adaptation and Ageing
2 Euromov DHM - EuroMov - Digital Health in Motion
3 CHU Pitié-Salpêtrière [AP-HP]
4 CHU Nîmes - Centre Hospitalier Universitaire de Nîmes
5 Clinique du Millénaire - Oc Santé [Montpellier]
6 CIC - Centre d'Investigation Clinique [Rennes]
7 Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Ponchaillou]
8 Polyclinique Saint Laurent [Rennes]
9 CIC 0004 - Nantes - Centre d'investigation clinique (CIC) de Nantes -CIC Plurithématique
10 CHU Nantes - Centre Hospitalier Universitaire de Nantes = Nantes University Hospital
11 TENS - The Enteric Nervous System in gut and brain disorders [U1235]
12 CHU Strasbourg - Centre Hospitalier Universitaire [Strasbourg]
13 IGBMC - Institut de Génétique et de Biologie Moléculaire et Cellulaire
14 ICM - Institut du Cerveau = Paris Brain Institute
15 B2A-IBPS - Adaptation Biologique et Vieillissement = Biological Adaptation and Ageing
Valérie Cochen de Cock
Connectez-vous pour contacter l'auteur
- Fonction : Auteur correspondant
- PersonId : 1136432
- IdHAL : valerie-cochen
- ORCID : 0000-0002-6460-4319
Connectez-vous pour contacter l'auteur
Smaranda Leu-Semenescu
- Fonction : Auteur
- PersonId : 762252
- ORCID : 0000-0001-9556-4527
Cécile Aerts
- Fonction : Auteur
Mathieu Anheim
- Fonction : Auteur
- PersonId : 1105631
Marie Vidailhet
- Fonction : Auteur
- PersonId : 1049214
Isabelle Arnulf
- Fonction : Auteur
- PersonId : 758801
- ORCID : 0000-0002-2240-2516
- IdRef : 078091179
Mohamed Doulazmi
- Fonction : Auteur
- PersonId : 1183442
- IdHAL : mohamed-doulazmi
- ORCID : 0000-0002-0313-1490
Emmanuel Roze
- Fonction : Auteur
- PersonId : 1020296
Résumé
Background: We recently demonstrated in a randomized controlled trial (APOMORPHEE, NCT02940912) that night-time only subcutaneous apomorphine infusion improves sleep disturbances and insomnia in patients with advanced Parkinson's disease and moderate to severe insomnia. Objectives: To identify the best candidates for receiving night-time only subcutaneous apomorphine infusion in routine care. Methods: In this post-hoc analysis of APOMORPHEE, we compared the characteristics of patients according to whether they chose to continue night-time only subcutaneous apomorphine infusion at the end of the study period or not. Results: Half of the patients (22/42) chose to continue the treatment. Off duration (day or night), painful Off dystonia, and insomnia severity at baseline were associated with night-time only apomorphine continuation. Multivariate analysis retained only Off duration as an independent predictor of continuation. Conclusions:The best candidates for night-time only apomorphine are patients with severe and prolonged Off periods (day or night) and severe insomnia.
Format du dépôt | Fichier |
---|---|
Type de dépôt | Article dans une revue |
Résumé |
en
Background: We recently demonstrated in a randomized controlled trial (APOMORPHEE, NCT02940912) that night-time only subcutaneous apomorphine infusion improves sleep disturbances and insomnia in patients with advanced Parkinson's disease and moderate to severe insomnia. Objectives: To identify the best candidates for receiving night-time only subcutaneous apomorphine infusion in routine care. Methods: In this post-hoc analysis of APOMORPHEE, we compared the characteristics of patients according to whether they chose to continue night-time only subcutaneous apomorphine infusion at the end of the study period or not. Results: Half of the patients (22/42) chose to continue the treatment. Off duration (day or night), painful Off dystonia, and insomnia severity at baseline were associated with night-time only apomorphine continuation. Multivariate analysis retained only Off duration as an independent predictor of continuation. Conclusions:The best candidates for night-time only apomorphine are patients with severe and prolonged Off periods (day or night) and severe insomnia.
|
Titre |
en
Night-Time Apomorphine Infusion: Who Are the Best Candidates?
|
Auteur(s) |
Valérie Cochen de Cock
1, 2
, Pauline Dodet
3
, Smaranda Leu-Semenescu
3
, Cécile Aerts
1, 2
, Beatriz Abril
4
, Giovanni Castelnovo
4
, Nicolas Landragin
5
, Sophie Drapier
6, 7
, Hélène Olivet
8
, Anne Gaelle Corbillé
9, 10
, Laurène Leclair-Visonneau
10, 11
, Mathieu Anheim
12, 13
, Marie Vidailhet
14, 3
, Isabelle Arnulf
3, 14
, Mohamed Doulazmi
15
, Emmanuel Roze
14, 3
1
Clinique Beau Soleil [Montpellier]
( 358772 )
- 119 avenue de Lodève | 34070 Montpellier
- France
2
Euromov DHM -
EuroMov - Digital Health in Motion
( 1100796 )
- Université de Montpellier UFR STAPS 700 avenue du Pic Saint Loup
34090 Montpellier
- France
3
CHU Pitié-Salpêtrière [AP-HP]
( 353778 )
- 47-83 Boulevard de l'Hôpital, 75013 Paris
- France
4
CHU Nîmes -
Centre Hospitalier Universitaire de Nîmes
( 361498 )
- 4 Rue du Professeur Robert Debré, 30029 Nîmes
- France
5
Clinique du Millénaire - Oc Santé [Montpellier]
( 463226 )
- 220 Boulevard Pénélope, 34000 Montpellier
- France
6
CIC -
Centre d'Investigation Clinique [Rennes]
( 2610 )
- Rue Henri Le Guilloux - Pavillon Clémenceau 35033 Rennes Cedex 9
- France
7
Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Ponchaillou]
( 301327 )
- 2 Rue Henri le Guilloux, 35000 Rennes
- France
8
Polyclinique Saint Laurent [Rennes]
( 1057376 )
- France
9
CIC 0004 - Nantes -
Centre d'investigation clinique (CIC) de Nantes -CIC Plurithématique
( 1160386 )
- Maison de la Recherche en Santé - 63 quai Magellan - 2éme étage Hall B - 44021 Nantes Cedex 1
- France
10
CHU Nantes -
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital
( 474972 )
- 1 Place Alexis-Ricordeau, 44000 Nantes
- France
11
TENS -
The Enteric Nervous System in gut and brain disorders [U1235]
( 1088539 )
- Faculté de Médecine,
1 rue Gaston Veil,
44035 Nantes
- France
12
CHU Strasbourg -
Centre Hospitalier Universitaire [Strasbourg]
( 300149 )
- France
13
IGBMC -
Institut de Génétique et de Biologie Moléculaire et Cellulaire
( 93800 )
- Parc D'Innovation 1 Rue Laurent Fries - BP 10142 67404 Illkirch Cedex
- France
14
ICM -
Institut du Cerveau = Paris Brain Institute
( 542029 )
- 47-83 Boulevard de l'Hôpital 75651 Paris Cedex 13
- France
15
B2A-IBPS -
Adaptation Biologique et Vieillissement = Biological Adaptation and Ageing
( 542094 )
- Campus de Jussieu - 4 place Jussieu 75005 Paris
- France
|
Nom de la revue |
|
Volume |
10
|
Numéro |
8
|
Page/Identifiant |
1192-1197
|
Date de publication |
2023-08
|
Audience |
Internationale
|
Vulgarisation |
Non
|
Comité de lecture |
Oui
|
Langue du document |
Anglais
|
Licence |
Paternité
|
Financement |
|
Domaine(s) |
|
Mots-clés |
en
Parkinson's disease, motor fluctuations, treatment, sleep, insomnia, sleepiness, apomorphine
|
DOI | 10.1002/mdc3.13799 |
Pubmed Id | 37635769 |
Fichier principal
Cochen De Cock - Night‐Time Apomorphine Infusion Who Are the Best Candidates.pdf ( 194.06 Ko
)
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