Fungal Endophytes: A Potential Source of Antibacterial Compounds - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Fungi Année : 2022

Fungal Endophytes: A Potential Source of Antibacterial Compounds

Sunil K Deshmukh
Hemraj Chhipa
Sanjai Saxena
Girish B Mahajan
Manish Kumar Gupta
  • Fonction : Auteur

Résumé

Antibiotic resistance is becoming a burning issue due to the frequent use of antibiotics for curing common bacterial infections, indicating that we are running out of effective antibiotics. This has been more obvious during recent corona pandemics. Similarly, enhancement of antimicrobial resistance (AMR) is strengthening the pathogenicity and virulence of infectious microbes. Endophytes have shown expression of various new many bioactive compounds with significant biological activities. Specifically, in endophytic fungi, bioactive metabolites with unique skeletons have been identified which could be helpful in the prevention of increasing antimicrobial resistance. The major classes of metabolites reported include anthraquinone, sesquiterpenoid, chromone, xanthone, phenols, quinones, quinolone, piperazine, coumarins and cyclic peptides. In the present review, we reported 451 bioactive metabolites isolated from various groups of endophytic fungi from January 2015 to April 2021 along with their antibacterial profiling, chemical structures and mode of action. In addition, we also discussed various methods including epigenetic modifications, co-culture, and OSMAC to induce silent gene clusters for the production of noble bioactive compounds in endophytic fungi.
Fichier principal
Vignette du fichier
[70]jof-08-00164.pdf (20.4 Mo) Télécharger le fichier
Origine Fichiers éditeurs autorisés sur une archive ouverte
Licence

Dates et versions

hal-04148745 , version 1 (03-07-2023)

Licence

Identifiants

Citer

Sunil K Deshmukh, Laurent Dufossé, Hemraj Chhipa, Sanjai Saxena, Girish B Mahajan, et al.. Fungal Endophytes: A Potential Source of Antibacterial Compounds. Journal of Fungi, 2022, 8 (2), ⟨10.3390/jof8020164⟩. ⟨hal-04148745⟩
7 Consultations
12 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More