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Article Dans Une Revue Physical Review E Année : 2023

Entry of microparticles into giant lipid vesicles by optical tweezers

Florent Fessler
Pierre Muller
Antonio Stocco

Résumé

Entry of micro-or nano-sized objects into cells or vesicles made of lipid membranes occur in many processes such as entry of viruses in host cells, microplastics pollution, drug delivery or biomedical imaging. Here, we investigated the microparticle crossing of lipid membranes in giant unilamellar vesicles in the absence of strong binding interactions (e.g. streptavidin-biotin binding). In these conditions, we observed that organic and inorganic particles can always penetrate inside the vesicles provided that an external picoNewton force is applied and for relatively low membrane tensions. In the limit of a vanishing adhesion, we pointed out the role of the membrane area reservoir and show that a force minimum exists when the particle size is comparable to the bendocapillary length.
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Dates et versions

hal-04128572 , version 1 (14-06-2023)

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Florent Fessler, Vaibhav Sharma, Pierre Muller, Antonio Stocco. Entry of microparticles into giant lipid vesicles by optical tweezers. Physical Review E , 2023, 107 (5), pp.L052601. ⟨10.1103/PhysRevE.107.L052601⟩. ⟨hal-04128572⟩
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