Risk of subsequent primary oral cancer in a cohort of 69,460 5-year survivors of childhood and adolescent cancer in Europe: the PanCareSurFup study
Ceren Sunguc
(1)
,
Mike M. Hawkins
(1)
,
David L. Winter
(1)
,
Isabelle M. Dudley
(1)
,
Emma J. Heymer
(1)
,
Jop C. Teepen
(2)
,
Rodrigue S. Allodji
(3, 4)
,
Fabiën Naomi Belle
(5, 6)
,
Francesca Bagnasco
(7)
,
Julianne M. Byrne
,
Edit Bárdi
(8)
,
Cećile M. Ronckers
(2, 9)
,
Nadia Haddy
(3, 4)
,
Thorgerdur Gudmundsdottir
(10, 11)
,
Stanislaw Garwicz
(12)
,
Moncilo Jankovic
(13)
,
Helena J.H. van der Pal
(2)
,
Maja Česen Mazić
(14)
,
Christina Schindera
(5, 15)
,
Desiree Grabow
(16)
,
Milena Maria Maule
(17)
,
Peter Kaatsch
(16)
,
Melanie Kaiser
(16)
,
Brice C. Fresneau
(3, 4)
,
Gisela Michel
(18)
,
Roderick Skinner
(19)
,
Thomas Wiebe
(12)
,
Carlotta Sacerdote
(17)
,
Zsuzsanna Jakab
(20)
,
Maria Winther Gunnes
(21, 22)
,
Monica Terenziani
(23)
,
Jeanette Falck Winther
(10, 24)
,
Päivi Maria Lähteenmäki
(25)
,
Lorna Zaletel
(26)
,
Claudia E. Kuehni
(5, 5)
,
Leontien C.M. Kremer
(2, 27)
,
Riccardo Haupt
(7)
,
Florent de Vathaire
(3, 4)
,
Lars Hjorth
(12)
,
Raoul C. Reulen
(1)
1
University of Birmingham [Birmingham]
2 Princess Máxima Center for Pediatric Oncology
3 CESP - Centre de recherche en épidémiologie et santé des populations
4 IGR - Institut Gustave Roussy
5 UNIBE - Universität Bern / University of Bern
6 UNIL - Université de Lausanne = University of Lausanne
7 IRCCS Istituto Giannina Gaslini [Genoa, Italy]
8 JKU - University of Linz - Johannes Kepler Universität Linz
9 OFFIS - Carl Von Ossietzky Universität Oldenburg = Carl von Ossietzky University of Oldenburg
10 DCSRC - Danish Cancer Society Research Center [Copenhagen, Denmark]
11 Landspitali National University Hospital of Iceland
12 Skane University Hospital [Lund]
13 UNIMIB - Università degli Studi di Milano-Bicocca = University of Milano-Bicocca
14 UMCL - University Medical Centre Ljubljana [Ljubljana, Slovenia]
15 Unibas - Université de Bâle = University of Basel = Basel Universität
16 JGU - Johannes Gutenberg - Universität Mainz = Johannes Gutenberg University
17 UNITO - Università degli studi di Torino = University of Turin
18 UNILU - Université de Lucerne = Universität Luzern
19 Newcastle University [Newcastle]
20 Semmelweis University [Budapest]
21 Oslo University Hospital [Oslo]
22 Cancer Registry of Norway
23 IRCCS Istituto Nazionale dei Tumori [Milano]
24 Aarhus University [Aarhus]
25 University of Turku
26 Institute of Oncology [Ljubljana]
27 UvA - University of Amsterdam [Amsterdam] = Universiteit van Amsterdam
2 Princess Máxima Center for Pediatric Oncology
3 CESP - Centre de recherche en épidémiologie et santé des populations
4 IGR - Institut Gustave Roussy
5 UNIBE - Universität Bern / University of Bern
6 UNIL - Université de Lausanne = University of Lausanne
7 IRCCS Istituto Giannina Gaslini [Genoa, Italy]
8 JKU - University of Linz - Johannes Kepler Universität Linz
9 OFFIS - Carl Von Ossietzky Universität Oldenburg = Carl von Ossietzky University of Oldenburg
10 DCSRC - Danish Cancer Society Research Center [Copenhagen, Denmark]
11 Landspitali National University Hospital of Iceland
12 Skane University Hospital [Lund]
13 UNIMIB - Università degli Studi di Milano-Bicocca = University of Milano-Bicocca
14 UMCL - University Medical Centre Ljubljana [Ljubljana, Slovenia]
15 Unibas - Université de Bâle = University of Basel = Basel Universität
16 JGU - Johannes Gutenberg - Universität Mainz = Johannes Gutenberg University
17 UNITO - Università degli studi di Torino = University of Turin
18 UNILU - Université de Lucerne = Universität Luzern
19 Newcastle University [Newcastle]
20 Semmelweis University [Budapest]
21 Oslo University Hospital [Oslo]
22 Cancer Registry of Norway
23 IRCCS Istituto Nazionale dei Tumori [Milano]
24 Aarhus University [Aarhus]
25 University of Turku
26 Institute of Oncology [Ljubljana]
27 UvA - University of Amsterdam [Amsterdam] = Universiteit van Amsterdam
Rodrigue S. Allodji
- Fonction : Auteur
- PersonId : 4839
- IdHAL : rodrigue-setcheou-allodji
- ORCID : 0000-0002-1895-8415
Francesca Bagnasco
- Fonction : Auteur
- PersonId : 1260536
- ORCID : 0000-0003-1601-9518
Julianne M. Byrne
- Fonction : Auteur
Cećile M. Ronckers
- Fonction : Auteur
- PersonId : 1260537
- ORCID : 0000-0003-3524-4657
Milena Maria Maule
- Fonction : Auteur
- PersonId : 1260538
- ORCID : 0000-0003-2142-1288
Brice C. Fresneau
- Fonction : Auteur
- PersonId : 1199184
- IdHAL : b-fresneau
- ORCID : 0000-0001-7603-7828
Gisela Michel
- Fonction : Auteur
- PersonId : 1260539
- ORCID : 0000-0002-9589-0928
Carlotta Sacerdote
- Fonction : Auteur
- PersonId : 763400
- ORCID : 0000-0002-8008-5096
Monica Terenziani
- Fonction : Auteur
- PersonId : 1260540
- ORCID : 0000-0002-7080-6718
Päivi Maria Lähteenmäki
- Fonction : Auteur
- PersonId : 1260541
- ORCID : 0000-0002-5500-9606
Lorna Zaletel
- Fonction : Auteur
- PersonId : 1260542
- ORCID : 0000-0002-4423-0276
Claudia E. Kuehni
- Fonction : Auteur
- PersonId : 804838
- ORCID : 0000-0001-8957-2002
- IdRef : 186420374
Leontien C.M. Kremer
- Fonction : Auteur
- PersonId : 1260543
- ORCID : 0000-0002-7619-7845
Riccardo Haupt
- Fonction : Auteur
- PersonId : 1260544
- ORCID : 0000-0003-0571-8460
Florent de Vathaire
- Fonction : Auteur
- PersonId : 1162629
- IdHAL : florent-de-vathaire
- ORCID : 0000-0002-8374-9281
Raoul C. Reulen
Connectez-vous pour contacter l'auteur
- Fonction : Auteur correspondant
- PersonId : 1260545
Connectez-vous pour contacter l'auteur
Résumé
Background: Survivors of childhood cancer are at risk of subsequent primary malignant neoplasms (SPNs), but the risk for rarer types of SPNs, such as oral cancer, is uncertain. Previous studies included few oral SPNs, hence large-scale cohorts are required to identify groups at risks. Methods: The PanCareSurFup cohort includes 69,460 5-year survivors of childhood cancer across Europe. Risks of oral SPNs were defined by standardised incidence ratios (SIRs), absolute excess risks and cumulative incidence. Results: One hundred and forty-five oral SPNs (64 salivary gland, 38 tongue, 20 pharynx, 2 lip, and 21 other) were ascertained among 143 survivors. Survivors were at 5-fold risk of an oral SPN (95% CI: 4.4–5.6). Survivors of leukaemia were at greatest risk (SIR = 19.2; 95% CI: 14.6–25.2) followed by bone sarcoma (SIR = 6.4, 95% CI: 3.7–11.0), Hodgkin lymphoma (SIR = 6.2, 95% CI: 3.9–9.9) and soft-tissue sarcoma (SIR = 5.0, 95% CI: 3.0–8.5). Survivors treated with radiotherapy were at 33-fold risk of salivary gland SPNs (95% CI: 25.3–44.5), particularly Hodgkin lymphoma (SIR = 66.2, 95% CI: 43.6–100.5) and leukaemia (SIR = 50.5, 95% CI: 36.1–70.7) survivors. Survivors treated with chemotherapy had a substantially increased risk of a tongue SPN (SIR = 15.9, 95% CI: 10.6–23.7). Conclusions: Previous radiotherapy increases the risk of salivary gland SPNs considerably, while chemotherapy increases the risk of tongue SPNs substantially. Awareness of these risks among both health-care professionals and survivors could play a crucial role in detecting oral SPNs early.
Domaines
Cancer
Origine : Accord explicite pour ce dépôt
Licence : CC BY - Paternité
Licence : CC BY - Paternité