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Article Dans Une Revue International Journal of Cancer Année : 2023

Baseline and lifetime alcohol consumption and risk of skin cancer in the European Prospective Investigation into Cancer and Nutrition cohort (EPIC)

1 CESP - Centre de recherche en épidémiologie et santé des populations
2 IGR - Institut Gustave Roussy
3 Oslo University Hospital [Oslo]
4 UiO - University of Oslo
5 ISPRO - Istituto per lo studio, la prevenzione e la rete oncologica = Institute for Cancer Research, Prevention and Clinical Network
6 CPO Piemonte - Centro di Riferimento per l'Epidemiologia e la Prevenzione Oncologica in Piemonte = Center for Cancer Prevention-Piemonte
7 Piedmont Centre for Drug Addiction Epidemiology, ASLTO3
8 UiT - University of Tromsø
9 Granada.ibs - Escuela Andaluza de Salud Publica
10 ibs.GRANADA Instituto de Investigación Biosanitaria [Granada, Spain]
11 CIBERESP - Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública
12 UGR - Universidad de Granada = University of Granada
13 IRCCS Istituto Nazionale dei Tumori [Milano]
14 Hyblean Association for Epidemiological Research
15 Università degli studi della Campania "Luigi Vanvitelli" = University of the Study of Campania Luigi Vanvitelli
16 Ministry of Health of the Basque Government
17 IIS Biodonostia - Biodonostia Health Research Institute [Donostia-San Sebastian, Spain]
18 Universidad de Murcia
19 Universidad de Antioquia = University of Antioquia [Medellín, Colombia]
20 IdiSNA - Navarra Institute for Health Research / Instituto de Investigación Sanitaria de Navarra
21 L’Hospitalet de Llobregat [Barcelona, Spain]
22 DKFZ - German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg]
23 DIfE - German Institute of Human Nutrition Potsdam-Rehbrücke
24 University of Potsdam = Universität Potsdam
25 Aarhus University [Aarhus]
26 DCSRC - Danish Cancer Society Research Center [Copenhagen, Denmark]
27 RIVM - National Institute for Public Health and the Environment [Bilthoven]
28 Skane University Hospital [Malmo]
29 Umeå University, Sweden
30 OMS / WHO - Organisation Mondiale de la Santé / World Health Organization Office [Genève, Suisse]
Reza Ghiasvand
Marit B. Veierod
Domenico Palli
  • Fonction : Auteur
Edoardo Botteri
Christina C. Dahm

Résumé

Experimental evidence suggests that alcohol induces cutaneous carcinogenesis, yet epidemiological studies on the link between alcohol intake and skin cancer have been inconsistent. The European Prospective Investigation into Cancer and Nutrition (EPIC) is a prospective cohort initiated in 1992 in 10 European countries. Alcohol intake at baseline and average lifetime alcohol intake were assessed using validated country-specific dietary and lifestyle questionnaires. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated in Cox models. A total of 14 037 skin cancer cases (melanoma: n = 2457; basal-cell carcinoma (BCC): n = 8711; squamous-cell carcinoma (SCC): n = 1928; unknown: n = 941) were identified among 450 112 participants (average follow-up: 15 years). Baseline alcohol intake was positively associated with SCC (>15 vs 0.1-4.9 g/day: HR = 1.44, 95% CI = 1.17-1.77; Ptrend =.001), BCC (HR = 1.12, 95% CI = 1.01-1.23; Ptrend =.04), and melanoma risks in men (HR = 1.17, 95% CI = 0.95-1.44; Ptrend =.17), while associations were more modest in women (SCC: HR = 1.09, 95% CI = 0.90-1.30; Ptrend =.13; BCC: HR = 1.08, 95% CI = 1.00-1.17, Ptrend =.03; melanoma: HR = 0.93, 95% CI = 0.80-1.08, Ptrend =.13). Associations were similar for lifetime alcohol intake, with an attenuated linear trend. Lifetime liquor/spirit intake was positively associated with melanoma (fourth vs first quartile: HR = 1.47, 95% CI = 1.08-1.99; Ptrend =.0009) and BCC risks in men (HR = 1.17, 95% CI = 1.04-1.31; Ptrend =.14). Baseline and lifetime intakes of wine were associated with BCC risk (HR = 1.25 in men; HR = 1.11-1.12; in women). No statistically significant associations were found between beverage types and SCC risk. Intake of beer was not associated with skin cancer risk. Our study suggests positive relationships between alcohol intake and skin cancer risk, which may have important implications for the primary prevention of skin cancer.
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Dates et versions

hal-04122321 , version 1 (22-06-2023)

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Yahya Mahamat-Saleh, Marie Al-Rahmoun, Gianluca Severi, Reza Ghiasvand, Marit B. Veierod, et al.. Baseline and lifetime alcohol consumption and risk of skin cancer in the European Prospective Investigation into Cancer and Nutrition cohort (EPIC). International Journal of Cancer, 2023, 152 (3), pp.348-362. ⟨10.1002/ijc.34253⟩. ⟨hal-04122321⟩
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