The French reference concept for the disposal of intermediate- and high-level nuclear waste in the Callovo-Oxfordian sedimentary rock formation (COX-claystone) considers the employment of crushed COX-claystone and its mixture with MX80-bentonite as potential backfill materials installed in drifts and shafts upon termination of the operational phase of the future repository. The fraction of MX80-bentonite in the mixture is limited to 30% in wet weight. Over time, the backfill will be saturated with solutions that originate in the surrounding rock formation and per-colate through the concrete lining left in place. The main characteristic of the leachate will be its high pH-value. In addition to the swelling pressure, the sealing properties of the backfill are de-termined by the hydraulic conductivity. This laboratory experimental study aimed to understand the hydraulic conductivity evolution of potential backfill materials under realistic conditions in terms of compaction conditions, solution chemistry, temperature and hydraulic gradient, and to relate results determined at the macroscale to results of microstructural and textural analysis. Also, the impact of the solution chemistry was evaluated by these means. In the case of mixture-samples, no stabilization of hydraulic conductivity was detected, despite the duration of the ex-periments being about one year. There was no detectable impact of the solution chemistry in the course of experiments attributable to low reaction kinetics under imposed conditions. Subse-quent microstructural analysis indicated material swelling triggering rearrangements in the pore space and lowering the fraction of hydraulic conductive voids. Interestingly, neither the satura-tion nor the solution chemistry had an impact on the texture of materials.